Flashcards in All about those microbes Deck (48):
What enzyme is responsible for the greenish color of pus?
Myeloperoxidase from azurphilic granules
Produced by neutrophils
Black eschar in nares of diabetic patient
Mucormycosis caused by mucor & rhizopus spp.
Partial circular, double-stranded DNA virus
Contains reverse transcriptase
Virion capable of infecting hepatocytes
Single stranded, linear DNA virus
Viruses that acquire envelopes by budding from nuclear membrane
Lancet-shaped gram positive cocci in pairs
*Most common cause of bacterial meningitis in adults!
Positive quellung reaction
Group B strep
Some nasty killers have some capsular protection. Go!
Bean-shaped gram negative cocci
Chocolate agar with factors V (NAD+) and X (hematin)
aka VPN- Vancomycin (inhibit gram positives), Polymyxin (inhibit gram negatives), & Nystatin (inhibits fungi)
Charcoal yeast extract agar buffered w/ cysteine & iron
Pink colonies on MacConkey's agar
Staph epidermidis- prosthetic devices, IV catheters
Strep mutans & strep sanguinis- dental plaques
Pseudomonas aeruginosa- cystic fibrosis pneumonia, contact lenses
Viridans group strep- endcarditis
Nontypable H. influenzae- otitis media
Abdominal rose spots
Comma-shaped, oxidase positive, gram negative organism that grows at 42 degrees C
Comma-shaped, oxidase positive, gram negative, grows in alkaline media
Gram-positive rod w/ tumbling motility
These viruses lose infectivity after being exposed to ether
Spherules packed with endospores
Hepatocytes w/ ground glass appearance
Capsule composed of D-glutamate
Grows in pre-existing lung cavities in immunocompromised pts
Agent of malignant otitis externa
Gram positive rod w/ metachromatic granules
Corynebacterium diphtheriae; contains AB exotoxin
B= binding subunit
A= active subunit (inhibits cell protein synthesis by inactivating EF2)
In response to injury, local neutrophils & macrophages release:
TNF-alpha, IL-1, & IL-6
Fever + productive cough + diarrhea
Evades host immune response by binding Fc region of Ig
S. aureus (Protein A)
Prevents opsonization & phagocytosis
Bacteria w/ red pigment
Virulence factor of group A strep
M protein- helps prevent phagocytosis
Which bacteria secrete IgA protease?
*enzyme that cleaves IgA * allows colonization of respiratory mucosa
Endotoxin induces the production of:
TNF & IL-1
Which bacteria inactivate elongation factor (EF-2)?
Corynebacterium diptheriae (Diptheria toxin)
Pseudomonas aeruginosa (Exotoxin A)
Voluminous 'rice-water' diarrhea
Caused by cholera toxin, which overactivates adenylate cyclase by permanently activating Gs :. increasing Cl- secretion in gut & H2O efflux
Which bacteria cleave SNARE protein?
Clostridium tetani (Tetanospasmin toxin)- prevents release of inhibitory (GABA & glycine) neurotransmitters in spinal cord :. muscle rigidity
Clostridium botulinum (Botulinum toxin)- prevents release of stimulatory (Ach) signals @ musculoskeletal junction :. flaccid paralysis
Which organisms cause toxic shock syndrome & how?
MOA: Bring MHC II & TCR together to cause massive release of IFN-gamma & IL-2
Strep pyogenes (Exotoxin A)
Staph aureus (Toxic shock syndrome toxin-1)
Associated w/ rusty sputum, sepsis in sickl cell anemia, & splenectomy
Strep pneumoniae (aka pneumococcus)
Formed by listeria to allow movement from cell to cell
Weil-felix reaction tests for. . .
Rickettsial infection (BUT it's negative for coxiella- Q fever)
Describe 2 forms of chlamydia
Elementary body- small dense, infections (Enfectious), enters cell via endocytosis
Reticulate body replicates in cell by fission; seen on tissue on culture