Wait, what? (Anesthetics)

Question 1

If a drug has low solubility in blood, what is the effect on induction and recovery times?

Answer 1

Low solubility in blood –> rapid induction & recovery times

Question 2

What type of drugs affect the CNS?

Answer 2

Lipid soluble (able to cross BBB)

OR

Actively transported drugs

Question 3

Thiopental

Answer 3

Barbiturate w/ high potency, high lipid solubility, & rapid entry into brain. Decreases cerebral blood flow.

Used for induction of anesthesia & short surgical procedures

Effect terminated by rapid redistribution into tissue & fat

Question 4

Midazolam

Answer 4

Benzodiazepine used for endoscopy

Used w/ gaseous anethetics & narcotics

May cause severe postoperative respiratory depression, decreased BP, & amnesia

Treat O/D w/ flumazenil

Question 5

Arylcyclohexylamine

Answer 5

Ketamine- PCP analog that acts as dissociate anesthetic

Block NDMA receptors

Cardiovascular stimulant. Increases blood flow.

Causes disorientation hallucination, & bad dreams.

Question 6

Propofol

Answer 6

Used for rapid anesthesia induction & short procedures. Less postoperative nausea than thiopental.

Potentiates GABA.

Question 7

Dantrolene

Answer 7

Prevents release of calcium from sarcoplasmic reticulum of skeletal muscle

Used to treat malignant hyperthermia caused by inhalation anesthetics & succinylcholine. Also treats neuroleptic malignant syndrome.