Farm a Sea Flashcards Preview

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Flashcards in Farm a Sea Deck (34):
1

Bethanechol

Cholinomimetic agent; direct agonist (mimics acetylcholine)

Uses: Postoperative & neurogenic ileus & urinary retention

Action: Activates bowel & bladder smooth muscle
Resistant to AChE

2

Carbachol

Cholinomimetic agent; direct agonist (mimics acetylcholine)

Uses: Glaucoma, pupillary contraction, relief of intraocular pressure

3

Pilocarpine

Cholinomimetic agent; direct agonist (mimics acetylcholine)

Uses: Potent stimulator of sweat, tears, saliva

Action: Constricts ciliary muscle of eye (open angle), pupillary sphincter (narrow angle)
Resistant to AChE

*You cry, drool, & sweat on your PILlow

4

Methacholine

Cholinomimetic agent; direct agonist (mimics acetylcholine)

Uses: Challenge test for diagnosis of asthma

Action: Stimulates muscarinic receptors in airway when inhaled

5

Neostigmine

Cholinomimetic agent; indirect agonist (Inactivates achetylcholinesterase)

Uses: Postoperative & neurogenic ileus & urinary retention; myasthenia gravis; reversal of neuromuscular junction blockade (postoperative)

Action: Increases endogenous ACh; no CNS penetration

6

Pyridostigmine

Cholinomimetic agent; indirect agonist (Inactivates acetylcholinesterase)

Uses: Myasthenia gravis (long-acting);

Action: Increases endogenous ACh; increases strength; no CNS penetration

7

Edrophonium

Cholinomimetic agent; indirect agonist (inactivates acetylcholinesterase)

Uses: Tensilon Test to diagnose myasthenia gravis (super short acting)

Action: Increases endogenous ACh

8

Physostigmine

Cholinomimetic agent; indirect agonist (Inactivates acetylchoinesterase)

Uses: Glaucoma; atropine overdose

Action: Increases endogenous ACh; crosses BBB

9

Echothiophate

Cholinomimetic agent; indirect agonist (Inactivates acetylcholinesterase)

Use: Glaucoma

Action: Increases endogenous ACh

10

Donepezil

Cholinomimetic agent; indirect agonist (inactivates acetylcholinesterase)

Use: Alzheimer's disease

Action: Increases endogenous ACh

11

Atropine

Muscarinic antagonist

Tx: bradycardia, opthalmic applications

**Don't give to pts w/ acute-angle glaucoma!!

12

Benztropine

Muscarinic antagonist

Use: Parkinson's

Action: Works in CNS

13

Scopolamine

Muscarinic antagonist

Use: Motion sickness

Action: Works on CNS; also decreases airway secretions

14

Ipratropium, Tiotropium

Muscarinic antagonist

Use: Asthma, COPD

Action: Works on respiratory system

15

Oxybutynin, Glycopyrrolate

Muscarinic antagonist

Use: Reduce urgency in mild cystitis & reduce bladder spasms

Action: Works on GU tract

16

Methscopolamine, Pirenzepine, Propantheline

Muscarinic antagonist

Tx: Peptic ulcers

Action: Works on GI tract

17

Epinephrine

Direct sympathomimetic

Acts on alpha 1, alpha 2, beta 1, beta 2

Tx: Anaphylaxis, open angle glaucoma, asthma, hypotension

18

Norepinephrine

Direct sympathomimetic

Acts on alpha 1 & 2 > beta 1

Tx: hypotension (beware: decreases renal perfusion)

19

Isoproterenol

Direct sympathomimetic

Acts on beta 1 and beta 2 only

Tx: AV block (rare)

20

Dopamine

Direct sympathomimetic

Acts on D1 at low dose, betas at medium dose, and alphas at high dose

Tx: Shock (renal perfusion), heart failure; inotropic & chronotropic

21

Dobutamine

Direct sympathomimetic

Acts on beta 1 most; some effect on alphas & B2

Tx: Heart failure, cardiac stress testing; inotropic but NOT chronotropic

22

Phenylephrine

Direct sympathomimetic

Acts on alpha 1 more than alpha 2

Tx: Pupillary dilation, vasoconstriction, nasal decongestion

23

Metaproterenol, Albuterol

Direct sympathomimetics

Act on beta 2 more than beta 1

Tx: acute asthma

24

Salmeterol

Direct sympathomimetics

Act on beta 2 more than beta 1

Tx: Long-term asthma treatment

25

Terbutaline

Direct sympathomimetics

Act on beta 2 more than beta 1

Reduces premature uterine contractions

26

Ritodrine

Direct sympathomimetic

Acts on beta 2

Reduces premature uterine contractions

27

Amphetamine

Indirect sympathomimetic; causes release of stored catecholamines

Treats narcolepsy, obesity, ADD

28

Ephedrine

Indirect sympathomimetic; releases stored catecholamines

Treats nasal decongestion, urinary incontinence, & hypotension

29

Cocaine

Indirect sympathomimetic; inhibits uptake

Causes vasoconstriction & local anesthesia

30

Clonidine

Sympathoplegic

Centrally acting alpha 2 agonist; decreases central adrenergic outflow

Treats hypertension, especially w/ renal disease (no decreased blood flow to kidney)

31

Phenoxybenzamine

Irreversible, non-selective alpha blocker

Treats pheochromocytoma (use before surgical removal)

Toxicity: orthostatic hypotension, reflex tachycardia

32

Phentolamine

Reversible, non-selective alpha blocker

Give to patients on MAO inhibitors who eat tyramine-containing foods

33

Prazosin, terazosin, doxazosin

Selective alpha-1 blocker

HTN, urinary retention in BPH

Toxicity: 1st dose orthostatic hypotension, dizziness, HA

34

Mirtazapine

Selective alpha-2 blocker

Treats depression

SE: sedation, elevated serum cholesterol, increased appetite