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Step One!!!! Kat's kontributions > Oncogenes & Tumor Suppressor Genes > Flashcards

Oncogenes & Tumor Suppressor Genes Flashcards

1
Q

abl

A

Oncogene
Associated w/ CML
Gene product: Tyrosine kinase

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2
Q

c-myc

A

Oncogene
Associated w/ Burkitt’s lymphoma
Gene product: Transcription factor

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3
Q

bcl-2

A

Oncogene
Associated w/ Follicular & undifferentiated lymphomas (inhibits apoptosis)
Gene product: Anti-apoptotic molecule

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4
Q

erb-B2

A

Oncogene
Associated w/ breast, ovarian, & gastric carcinomas
Gene product: Tyrosine kindase

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5
Q

ras

A

Oncogene
Associated w/ colon carcinoma, pancreatic adenocarcinoma
Gene product: GTPase

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6
Q

L-myc

A

Oncogene
Associated w/ Lung tumor
Gene product: Transcription factor

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7
Q

N-myc

A

Oncogene
Associated w/ neuroblastoma
Gene product: Transcription factor

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8
Q

ret

A

Oncogene
Associated w/ MEN IIA & MEN IIB
Gene product: Tyrosine kinase

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9
Q

c-kit

A

Oncogene
Associated w/ GI stromal tumor
Gene product: Cytokine receptor

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10
Q

Rb

A

Tumor Suppressor Gene
Associated w/ retinoblastoma, osteosarcoma
Gene product: Rb gene product blocks G1 –> S phase of the cell cycle

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11
Q

p53

A

Tumor Suppressor Gene
Associated w/ most human cancers, especially Li-Fraumeni syndrome
Gene product: p53 product blocks G1 –> S phase of the cell cycle

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12
Q

BRCA1

A

Tumor Suppressor Gene
Associated w/ breast & ovarian cancer
Gene product: DNA repair protein

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13
Q

BRCA2

A

Tumor Suppressor Gene
Associated w/ breast cancer
Gene product: DNA repair protein

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14
Q

p16

A

Tumor Suppressor Gene

Associated w/ melanoma

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15
Q

APC

A

Tumor Suppressor Gene

Associated w/ colorectal cancer (associated w/ FAP)

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16
Q

WT1

A

Tumor Suppressor Gene

Associated w/ Wilms’ tumor

17
Q

NF1

A

Tumor Suppressor Gene

Associated w/ Neurofibromatosis Type I

18
Q

NF2

A

Tumor Suppressor Gene

Associated w/ Neurofibromatosis Type II

19
Q

DPC

A

Tumor Suppressor Gene

Associated w/ Pancreatic cancer

20
Q

DCC

A

Tumor Suppressor Gene

Associated w/ colon cancer

21
Q

VHL

A

Tumor Suppressor Gene
Associated w/ Renal Cell Carcinoma, VHL Syndrome
Gene product: Ubiquitin ligase component

Step One!!!! Kat's kontributions (28 decks)

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