Keep Bleeding Flashcards Preview

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Flashcards in Keep Bleeding Deck (12):
1

Heparin

Cofactor for activation of antithrombin

2

Lepirudin, bivalirudin

Directly inhibit thrombin

Good alternative for patients w/ HIT

3

Warfarin

Interferes w/ normal synthesis & gamma-carboxylation of vitamin K dependent clotting factors II, VII, IX, X, and proteins C & S

4

Thrombolytics

Directly or indirectly aid conversion of plasminogen to plasmin, which cleaves thrombin & fibrin clots

5

Streptokinase

Thrombolytic

6

Urokinase

Thrombolytic

7

tPa

Thrombolytic

AKA alteplase

8

APSAC

Thrombolytic

AKA antistreplase

9

Aspirin

Acetylates & irreversibly inhibits COX 1 & COX 2

10

Clopidogrel, ticlopidine

Inhibit platelet aggregation by irreversibly blocking ADP receptors; inhibit fibrinogen binding by preventing glycoprotein IIb/IIIa expression

11

Cilostazol, dipyridamole

Phosphodiesterase III inhibitors; increase cAMP in platelets thus inhibiting platelet aggregation; vasodilators

12

Abciximab

Monoclonal antibody that binds glycoprotein receptor IIb/IIIa on activated platelets, preventing aggregation