Aminoglycosides

Question 1

What CrCl should aminoglycosides be avoided in?

Answer 1

<20ml/min

Question 2

What infection is streptomycin almost entirely reserved for?

Answer 2

TB- only aminoglycoside active against mycobacterium tuberculosis

Question 3

Spectrum cover

Answer 3

Broad-spectrum negative, some positive and pseudomonas aureginosa

Question 4

What other antibacterials are often used alongside aminoglycosides?

Answer 4

Pencillins for gram positive cover and metronidazole to cover for anaerobes

Question 5

Mehtod of administration?

Answer 5

IV/IM due to poor gut absorption

Question 6

CI to aminoglycosides

Answer 6

Mysathenia Gravis + perforated ear conditions

Question 7

SEs of aminglycosides

Answer 7

Ototoxicity

Nephrotoxicity

Skin reactions

Tinnitus

Nausea and vomiting

Peripheral neuropathy

Question 8

What should pre-dose trough level of gentamicin be?

Answer 8

2mg/L

Question 9

Target peak concentration of gentamicin after 1 hour

Answer 9

5-10mg/L

Question 10

MHRA warning for aminoglycosides

Answer 10

Risk of deafness in mitochondrial mutations

Question 11

What are loading and maintenance doses of gentamicin based off?

Answer 11

Weight and renal function + use of nomogram

Question 12

Which patient groups would you expect high doses of gentamicin in?

Answer 12

Neonates and the immunocompromised

Question 13

Maximum recommended course length for aminoglycosides

Answer 13

7 days

Question 14

Which patient groups must aminoglycosides serum concetrations be monitored?

Answer 14

Obesity, CF, elederly, renal impairment, high doses