Cephalosporins Flashcards
(9 cards)
Indications for 1st and 2nd generation cephalosporins
soft tissue infections (Do not cross the BBB)
Indications for 3rd generation cephalosporins
Cross the BBB so used for serious gram negative infections e.g., pseudomnas, menigitis
Which generation of Cephalosporins offer the most coverage for gram negative infections?
5th generation- Gram negative cover increases with each generation
Indications for cephalosporins
Septicaemia, pneumonia, meningitis, and UTIs
Which cephalosporins are used for CNS infections?
Ceftriaxone and Cefotaximine
Which group of antibiotics can cross-sensitivity occur with Cephalosporins?
Penicillins
Which group of antibitoics should cephalosporins not be used with due to increased risk of nephrotoxicity?
Aminoglycosides
How are cephalosporins excreted?
Renally
Which generations of cephalosporins are most associated with C.difficile?
2nd and 3rd generations
