Carbapenems Flashcards
(9 cards)
1
Q
Method of administration
A
IV only
2
Q
Cover of Carbapenems
A
Broad-spectrum BUT no atypical cover
3
Q
Indications for carbapenems
A
Hospital acquired septicaemia
CAP
Meningitis
Endocarditis
Diabetic foot infections
4
Q
CI of Meropenem
A
Epilepsy/ seizure history as increased risk
If immediate hypersensitivity reaction to beta-lactams
5
Q
When is neurological toxicity more likely to occur with Meropenem use?
A
In high doses or renal impairment
6
Q
What monitoring is required whilst on Meropenem?
A
LFTs- due to risk of hepatotoxicity
7
Q
How do you treat carbapenem associated seizures?
A
With a benzodiazepine
8
Q
Interaction with which anti-epileptic and effect?
A
Sodium valproate- decreases the efficacy
9
Q
Effect of Meropenem on warfarin?
A
Increases warfarin level and anticoagulant effect
