Tetracyclines

Question 1

Tetracycline cover

Answer 1

Positive, negative, atypical, and MRSA

Question 2

Why is minocycline not used for meningococcal prophylaxis anymore?

Answer 2

Due to SEs of dizziness and vertigo

Question 3

Indications for tetracyclines

Answer 3

Lower respiratory tract infections

Acne

Rosacea

Malaria

Chlamydia

Question 4

CI for tetracyclines

Answer 4

Avoid in children under 12- bind to teeth and bones and can affect them

Pregnancy (can be used for malaria prophylaxis up to 15 weeks gestation)

Breastfeeding

Myasthenia gravis

Alcohol dependence

Question 5

Counselling points for Doxycyline

Answer 5

Take with water during meal times whilst sitting or standing to avoid oesophageal irritation

Avoid direct sunlight/artificial UV rays, can cause photosensitivity reactions

Spare 2 hours before or after before taking dairy, indigestion remedies, or products containing zinc, iron, or calcium

Question 6

SEs of Tetracyclines

Answer 6

GI disturbances

Photosensitivity

Tooth enamel discolouration in children

Hypersensitivity reactions

Minocycline can cause irreversible pigmentation

Question 7

MOA

Answer 7

Inhibit bacterial protein sysnthesis by binding to ribosomal 30S subunit