Clindamycin

Question 1

MOA of clindamycin

Answer 1

Inhibition at ribosomal 50S subunit

Question 2

Cover of clindamycin

Answer 2

Gram positive and anaerobes- NO action again gram negative organisms

Question 3

CI of clindamycin

Answer 3

History of GI disease/colitis

Avoid use in acute porphyria’s (intermittent attacks of abdominal pain and neurological symptoms)

Question 4

Counselling points for clindamycin

Answer 4

Seek medical advice if experience diarrhoea when taking (high risk of C. diff)

May have a metallic taste when taking orally

2% cream may damage latex condoms and diaphragms

Question 5

SEs of clindamycin

Answer 5

Diarrhoea

Antibiotic associated colitis

Skin reactions

Abdominal pain

Nausea and vomiting