Anemia Flashcards
(49 cards)
Classification of anemia in males
Why men have more oxygen carrying capacity than women
Testosterone production drives hemoglobin synthesis
The percent of blood that is RBCs compared to plasma
Hematocrit
Hemoglobin and hematocrit levels in acute blood loss
Normal at 1st but low after fluid recessitation
Lysis of erythrocytes
Hemolysis
2 groups of antibodies that commonly cause hemolysis
- ITP, TTP (thrombocytopenia purpura)
2. Transfusion mismatch
Why hemoglobin measurement is unreliable in hemolysis
When cells break they dump hemoglobin into the plasma
Broken cells/ RBC fragments seen on a peripheral smear that indicate that hemolysis is occuring
Schistocytes
A circulating protein whose function is to bind and transport free (from lysed RBCs) to the blood forming organs (liver and bone marrow) for recycling of iron
Haptoglobin
2 things that low haptoglobin can indicate
- Liver isn’t functioning and cannot make new proteins
2. Hemolysis is occuring
3 vaccines needed for spleenectomy
- Prevnar
- Mennigitis
- Influenza
(Incapsulated bacteria)
An abnormal recessive composition of alpha or beta hemoglobin chains in which abnormal RBCs are subject to lysis
Thalassemia
Morphologic classification of anemia due to Thalassemia
microcytic
RBC appearance in Thalassemia
looks like a target
Most common group of people to have Thalassemia
Individuals of African or Mediterranean origin
A recessive, X-linked SNP that renders RBC membranes susceptible to oxidative stress
G6PD deficiency
Morphologic classification of anemia due to G6PD deficiency
Normocytic
Hematocrit / RBC number (describes the mean size of a single RBC)
MCV (Mean Corpuscular Volume)
Normal MCV value
80 - 100 fl
Morphologic classification of anemia due to iron deficiency
Microcytic
The abnormal, irresistible craving to eat weird stuff
Pica
Recommended daily elemental iron in males 14 - 18 y/o
11 mg/day
Recommended daily elemental iron in males > 18 y/o
8 mg/day
Recommended daily elemental iron in females 14 - 18 y/o
15 mg/day
