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Flashcards in Anemia Deck (49):
1

Classification of anemia in males

2

Why men have more oxygen carrying capacity than women

Testosterone production drives hemoglobin synthesis

3

The percent of blood that is RBCs compared to plasma

Hematocrit

4

Hemoglobin and hematocrit levels in acute blood loss

Normal at 1st but low after fluid recessitation

5

Lysis of erythrocytes

Hemolysis

6

2 groups of antibodies that commonly cause hemolysis

1. ITP, TTP (thrombocytopenia purpura)
2. Transfusion mismatch

7

Why hemoglobin measurement is unreliable in hemolysis

When cells break they dump hemoglobin into the plasma

8

Broken cells/ RBC fragments seen on a peripheral smear that indicate that hemolysis is occuring

Schistocytes

9

A circulating protein whose function is to bind and transport free (from lysed RBCs) to the blood forming organs (liver and bone marrow) for recycling of iron

Haptoglobin

10

2 things that low haptoglobin can indicate

1. Liver isn't functioning and cannot make new proteins
2. Hemolysis is occuring

11

3 vaccines needed for spleenectomy

1. Prevnar
2. Mennigitis
3. Influenza
(Incapsulated bacteria)

12

An abnormal recessive composition of alpha or beta hemoglobin chains in which abnormal RBCs are subject to lysis

Thalassemia

13

Morphologic classification of anemia due to Thalassemia

microcytic

14

RBC appearance in Thalassemia

looks like a target

15

Most common group of people to have Thalassemia

Individuals of African or Mediterranean origin

16

A recessive, X-linked SNP that renders RBC membranes susceptible to oxidative stress

G6PD deficiency

17

Morphologic classification of anemia due to G6PD deficiency

Normocytic

18

Hematocrit / RBC number (describes the mean size of a single RBC)

MCV (Mean Corpuscular Volume)

19

Normal MCV value

80 - 100 fl

20

Morphologic classification of anemia due to iron deficiency

Microcytic

21

The abnormal, irresistible craving to eat weird stuff

Pica

22

Recommended daily elemental iron in males 14 - 18 y/o

11 mg/day

23

Recommended daily elemental iron in males > 18 y/o

8 mg/day

24

Recommended daily elemental iron in females 14 - 18 y/o

15 mg/day

25

Recommended daily elemental iron in females 19 - 50 y/o

18 mg/day

26

Recommended daily elemental iron in pregnancy

27 mg/day

27

Recommended daily elemental iron in lactation

9 mg/day

28

Carrier protein that carries iron

Transferrin

29

1 microcytic anemias that commonly resemble iron deficiency

1. Thalassemia
2. Chronic heavy metal exposure

30

Usual treatment dose for iron deficiency

200 mg elemental iron per day

31

Duration of iron therapy once hemoglobin has normalized

3 - 6 months

32

% elemental iron in ferrous sulfate

20 %

33

% elemental iron in ferrous gluconate

12%

34

% elemental iron in ferrous fumarate

33%

35

Morphologic classification of anemia due to Vitamin B12 deficiency

Macrocytic

36

Autoimmune disease of gastric parietal cells with subsequent loss of intrinsic factor that causes inability to absorb Vit B12

Pernicious anemia

37

Morphological classification of anemia in folate deficiency

macrocytic

38

Classification of anemia in females

39

The most populous WBCs that are the body's primary defense mechanism against microbial invasion

Neutrophils

40

Left shift in blood cells

The presence of immature forms of neutrophils in peripheral blood

41

3 clinical concern in thrombocytosis

clotting, hemorrhage, migraine

42

2 clinical concerns in thrombocytopenia

bleeding,hemorrhage

43

4 clinical concerns with erythrocytosis/polycythemia

Increased blood viscosity
HTN
Thrombosis (clotting)
Bleeding

44

High hemoglobin

polycythemia/erythrocytosis

45

High eosinophils

Eosinophilia

46

Clinical concerns with eosinophelia

clinically benign but concern about the underlying cause

47

High WBCs

Leukocytosis

48

Clinical concern with leukocytosis

Usually clinically benign unless extreme but concerned about underlying cause

49

(% neutrophils + % bands) x WBC

Absolute Neutrophil Count (ANC)