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Flashcards in Parkinson's pharmacology Deck (16):
0

A form of secondary parkinson's disease that is caused by a viral infection

postencephalitic parkinsonism

1

Part of the basal ganglia where dopamine is synthesized

substantia nigra

2

DA receptors that are GPCRs that are generally excitatory

D1type (D1 and D5)

3

The most effective treatment of parkinson's disease

levodopa

4

MOA of carbidopa

peripheral dopa decarboxylase inhibitor

5

MOA of entacopone

inhibits COMT in periphery

6

MOA of tolcapone

Inhibits COMT in periphery and CNS

7

Major risk associated with tolcapone

hepatic failure

9

Ergot D2-dopamine receptor agonist and partial D1 antagonist

Bromocriptine

10

MAO-B inhibitor that is not metabolized to amphetamine

resagiline

12

2 non-ergot D2 and D3 receptor agonists

Pramiprexole
Ropinirole

13

A dopamine receptor antagonist that is a SQ injection that is indicated for the acute, intermittent treatment of hypomobility, "off" episodes in advanced PD

apomorphine (Apokyn)

14

Anti-emetic therapy commonly used with apomorphine

trimethobenzamide

15

Anti-viral agent that can also be used in PD because it increases DA release and blocks NMDA receptors

amantadine

16

MAO-B inhibitor that has an amphetamine metabolite

selegiline

20

DA receptors that are GPCRs that are generally inhibitory

D2 type (D2, D3 and D4)