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Flashcards in Pain Pharmacology Deck (39):
0

Amount of time that qualifies pain as chronic

3 months

1

Pain that permits the localization of pain and discriminates among different types of pain

somatic

2

Pain that activates circuits in the brain that produces negative emotions

Affective pain

3

Brain region that is important in fear

amygdala

4

Nociceptive fibers that are unmyelinated and have a conduction speed of less than 2 sec

C fibers

5

MOA of pentazocaine

partial mu agonist and k agonist

6

receptors that mediate long lasting increase in excitability of dorsal horn neurons

NMDA receptors

7

4 AAs that are at the N-terminus of all endogenous opioid receptor agonists

Tyr-Gly-Gly-Phe

8

4 endogenous opioid receptor agonists

B-endorphin
Met-enkephalin and Leu-enkephalin
Dynorphin

9

MOA of buprenorphine

partial mu agonist and possible k antagonist

10

4 effects of mu-opioid receptors

1. analgesia
2. sedation
3. inhibition of respiration
4. slowed GI transit

11

3 effects of kappa-opioid receptors

1. analgesia
2. psychometic effects
3. slowed GI transit

12

inactive metabolite of morphine with neurotoxic properties

M3G

13

MOA of butorphanol

partial mu agonist and k agonist

14

active metabolite of morphine that is more active than the parent

M6G

15

Mechanism by which respiratory depression du to opioids is mediated

me receptor-mediated

16

Main MOA of lidocaine

blocks Na channel function

17

MOA of methadone

mu receptor agonist and NMDA receptor antagonist

18

Opioid antagonist that is used in alcohol addiction

Naltrexone

19

MOA of tramadol metabolite

weak mu receptor agonist

20

Stimuli that normally do not cause pain now cause pain

Allodynia

21

MOA of nalbuphine

mu antagonist and k agonist

22

FDA approved use of methylnaltrexone

refractory opioid-induced constipation in patients with acute illness receiving palliative care

23

mechanism by which euphoria due to opioids is mediated

mu receptor-mediated

24

Mechanism by which nausea/vomiting due to opioids is mediated

activation of chemoreceptor trigger zone

25

released from free nerve endings and activates adjacent nociceptive neurons by binding to NKI receptors and contributes to pain and inflammation

Substance P

26

3 actions of Gi/o opioid receptor channels

1. open K channels
2. closing Ca channels
3. inhibit adenylate cyclase

27

MOA of aspirin

irreversibly inhibits COX via acetylation

28

ligand-gated non-selective ion channel on C fiber sensory neurons that capsaicin activates

transient receptor potential vanilloid (TRPVI) receptor

29

MOA of triptans

1B/1D receptor agonist

30

An intrathecal spinal infusion of come snail venom

Zoconitide

31

3 effects of substance P

1. vasodilation
2. aids in generation of bradykinin from kininogen
3. release of histamine from mast cells

32

2 side effects of opioids that patients do not develop tolerance to

1. constipation
2. Miosis

33

An alkaloid derived from plants of the Solanacae family that causes local depletion of Substance P

Capsaicin

34

MOA of zoconitide

blocks presynaptic N-type Ca channels, decreasing excitatory neurotransmitter release

35

Opioid antagonist that is the primary agent used for opioid overdose

Naloxone

36

MOA of methylnaltrexone

peripherally acting mu-opioid receptor antagonist

37

MOA of tramadol parent drug

5HT/NE reuptake inhibition

38

nociceptive neurons that are thinly myelinated and have a conduction speed of 20 m/sec

Adelta fibers