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Flashcards in Pulmonary pharmacology Deck (49):
0

3 effects of alpha adrenergic stimulation

1. smooth muscle contraction
2. vasoconstriction
3. slight bronchoconstriction

1

Antibody that is cross-linked by allergens and activates mast cell degranulation, producing asthma symptoms

IgE

2

Th cells that are important in cell-mediated immunity and intracellular pathogens

Th1

3

3 effects of beta-1 adrenergic stimulation

1. tachycardia
2. arrhythmia
3. HTN

4

Major effect beta-2 stimulation

bronchodilation

5

Th cells that can cause chronic inflammation and are thought to be associated with neutrophilic asthma

Th17

6

A severe whole body response to an allergen leading to smooth muscle constriction, vasodilation (hypotension) and increased vascular permeability

anaphylaxis

7

Enzyme that is inhibited by PKA (via phosphorylation) that catalyzes muscle contraction

Myosin light chain kinase (MLCK)

8

G-alpha subunit that is associated with beta-2 receptors

Gs

9

The standard emergency treatment for anaphylaxis

epinephrine

10

3 ultra-long acting beta-2 agonist

1. indacaterol
2. olodaterol
3. vilanterol

11

Th cells that are important in antibody-related immunity and extracellular pathogens and are thought to be associated with eosinophilic asthma

Th2

12

Traditional Chinese remedy for asthma that is a non-selective adrenergic agonist

Ephedrine

13

Drug class of theophylline

methylxanthine

14

Zone for the cortex that is responsible for producing mineralcorticoids (aldosterone)

zona glomerulosa (outer)

15

2 long-acting inhaled beta-2 agonists

1. salmeterol (Serovent)
2. formoterol (Foradil)

16

The gold standard short-acting beta-2 agonist

albuterol

17

3 MOAs of theophylline

1. phosphodiesterase inhibitor
2. adenosine receptor antagonist
3. activation of histone deacetylases

18

2 IV beta-2 agonists

1. terbutaline
2. epinephrine

19

Zone of the cortex that is responsible for producing sex hormones

zona reticularis (inner)

20

Long-acting beta-2 agonist that is a partial agonist

salmeterol xiafoate

21

Region of the adrenal gland that secretes mineralcorticoids, glucocorticoids and sex hormones

Cortex (outer region)

22

2 major problems with theophylline, largely limiting its use

1. low therapeutic index
2. many drug interactions

23

MOA of roflumilasat

Phosphodiesterase 4 inhibitor

24

Muscarinic receptor that is mostly active in airway smooth muscle contraction and mucus hyper-secretion

M3

25

The first line of defense for treating COPD

anticholinergics

26

2 oral beta-2 agonists

1. terbutaline
2. albuterol

27

Region of the adrenal gland that secretes catacholamines

Medulla (inner region)

28

Structural difference between anticholinergics used to treat COPD and atropine

agents used to treat COPD are quaternary amines

29

Zone of the cortex that is responsible for producing glucocorticoids

zona fasciculata (middle)

30

The precursor for cortisol

cholesterol

31

Where ACTH is released from

pituitary gland

32

Protein that translocates free cholesterol to the mitochondria and transports cholesterol from the outer membrane to the inner membrane

Steriodogenic acute regulator protein

33

Hormone that regulates the zona fasciculata and the production of glucocorticoids

Adrenocorticotropic hormone (ACTH)

34

MOA of zilueton

5'- lipoxygenase inhibitor

35

Muscarinic receptors that are presynaptic and ideally would not be inhibited

M2

36

Location of the adrenal gland

above the kidneys

37

3 MOAs of theophylline that relate to asthma

1. Phosphodiesterase inhibitor
2. adenosine receptor antagonist
3. activation of histone deacetylases

38

MOA of decongestants (phenylephrine and pseudophedrine)

alpha-1 adrenergic receptor agonists

41

G alpha subunit associated with alpha-1 adrenergic receptor

Gq

42

1st line maintenance therapy for asthma

ICS

43

2 Mast cell stabilizers

1. Cromolyn
2. Nedocromil

45

Maximum usage time of topical nasal decongestants

every 12 hours for no longer than 3-5 days

46

Standard dosing regimen of cromolyn (mast cell stabilizer) for maintenance treatment of asthma

2 inhalations qid

47

Target of montelukast

LT1 receptor

48

GPCR alpha subtype in LT1 receptor

Gq

49

Condition characterized by vicious cycle of nasal decongestant therapy followed by congestion

rhinitis medicamentosa

50

G-alpha subunit associated with H1 receptor

Gq

51

2 major effects of histamine H1 receptor activity

1. NO-mediated relaxation of smooth muscle, vasodilation
2. MLCK-mediated contraction capillary endothelium, making capillaries leaky