Anti-arrhythmic Agents Flashcards Preview

Nur 30 Pharmacology > Anti-arrhythmic Agents > Flashcards

Flashcards in Anti-arrhythmic Agents Deck (9):
1

Class I Anti-arrhythmic Agent

Lidocaine: Blocks Na+ Channels

Indications: Management of acute ventricular arrhythmias during cardiac surgery or MI

Actions: Decreases depolarization, decreasing automaticity of the ventricular cells; increases ventricular fibrillation threshold.

2

Lidocaine adverse effects:

Anaphylactoid reactions, hypotension, vasodilation, cardiac arrest

Don't mix with digoxin, risk for arrhythmia increases.

3

Class II Anti-arrhythmic Agent

Propanolol: Beta blockers

Indications: Treatment of...

1. Cardiac arrhythmias
2. Especially SVT
3. Treatment of ventricular tachycardia induced by digitalis or catecholamines.

4

Propanolol Actions

1. Competitively blocks beta-adrenergic receptors in the heart and kidney, has a membrane-stabilizing effect, and decreases the influence of the sympathetic nervous system.

Don't mix with insulin, hypoglycemia happens.

5

Propanolol Adverse Effects

1. Decreased exercise intolerance
2. antinuclear antibody development
3. pulmonary edema
4. gastric pain
5. cerebrovascular accident
6. heart blocks

6

Class III Anti-arrhythmic Agent

Amiodarone: K+

Treatment of life-threatening ventricular arrhythmias

Actions: Acts directly on hear muscle cells to prolong repolarization and the refractory period, increasing the threshold for V. Fib; also acts on peripheral smooth muscle to decrease peripheral resistance.

7

Amiodarone adverse effects

Malaise
Hepatoxicity
Constipation
Corneal microdeposits
Pulmonary toxicity

DONT MIX WITH ANTIHISTAMINES, PHENOTHIAZINES OR ANTIDEPRESSANTS

8

Class IV Anti-arrhythmic Agent

Diltiazem: Ca+ channel blockers

Indications: Treatment of...

1. Paraoxysmal SVT
2. A. Fib
3. Atrial flutter

Actions: Blocks movement of Ca across the cell membrane, depressing the generation of action potentials slowing conduction of AV node.

9

Diltiazem adverse effects.

Peripheral edema
AV block
Asthenia (abnormal lack of energy)
Hepatic injury