Flashcards in Immune Chapters Deck (22):
Treatment of mild to moderate pain, fever, inflammatory conditions; reduction of risk of transient ischemic attack or stroke; reduction of risk of myocardial infarction
Inhibits the synthesis of prostaglandins; blocks the effects of pyrogens at the hypothalamus; inhibits platelet aggregation by blocking thromboxane A2
Salicylates (CI - DD)
Chicken pox or influenza (reye syndrome in children and teenagers)
procedures schedules within 1 week
history of nasal polyps, asthma, chronic urticara.
many cus of the alteration on absorption, and effects on the liver
occult blood loss
NSAID (I - A)
Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis; relief of mild to moderate pain;treatment of primary dysmenorrhea; fever reduction
Inhibits prostaglandin synthesis by blocking COX 1 and 2 receptor sites, leading to an anti-inflammatory effect, analgesia, and antipyretic effects.
NSAID (CI - DD)
Peptic ulcer or known GI bleeding
Decreased diuretic effects if taken with loop diuretic
Decreased antiHTN effects if taken with beta blockers
Lithium toxicity with ibuprofen
Acetaminophen (I - A)
Treatment of mild to moderate pain, fever, or signs and symptoms of the common cold or flu. Musculoskeletal pain associated with arthritis and rheumatic disorders.
Acts directly on the hypothalamus to cause vasodilation and sweating, which will reduce fever; mechanism of action as an analgesic not understood.
Acetaminophen (CI - DD)
Increased risk of bleeding with anticoags
hepato-toxicity with barbiturates.
Immune Stimulant (I - A)
Hairy cell leukemia, malignant melanoma, AIDS-related kaposi sarcoma, chronic hep B, and C, intralesional treatment of condylomata acuminata in PT 18+
Inhibits the growth of tumor cells and enhances the immune response
Immune Stimulant (CI - DD)
Women use condoms pls
Cardiac disease (HTN dysrhythmias reported)
CNS dysfunction (CNS depression)
Immune Stimulant (AE)
Flu like syndrome
bone marrow suppression
Interleukin (I - A)
Metastatic renal cell carcinoma in adults, treatment of metastatic melanomas (orphan drug use)
Activates human cellular immunity and inhibits tumor growth through increases in lymphocytes, platelets, and cytokines.
Interleukin (CI - DD)
CI: allergy to E.coli
Women use condoms pls
Mental status changes, sinus tachycardia
arrhythmias, bone marrow supression
Resp. difficulties, hypotension
T and B cell suppressors (I)
Prophylaxis for organ rejection in kidney, liver, and heart transplants (used with corticosteroids)
treatment of chronic rejection in patients previously treated with other immune suppressants, treatment of rheumatoid arthritis and recalcitrant psoriasis.
T and B cell suppressors (A)
Reversibly inhibits immunocompetent lymphocytes; inhibits T helper cells and T suppressor cells, lymphokine production, and release of interleukin-2 and T cell growth factor .
T and B cell suppressors (CI - DD)
CI: presence of known neoplasms
D-D: other drugs that are hepatotoxic or nephrotoxic
T and B cell suppressors (AE):
increased risk for infection
MMR ( Measles Mumps Rubella)
Active immunization against measles, mumps and rubella in children older than 15 months and adults
Attenuated MMR viruses produce a modified infection and stimulate an active immune reaction with the production of antibodies.
MMR (CI - DD)
allergies to known components of the vaccine
who have received blood products in the last 3 months