Chapter 28 - NMJ Blockers Flashcards Preview

Nur 30 Pharmacology > Chapter 28 - NMJ Blockers > Flashcards

Flashcards in Chapter 28 - NMJ Blockers Deck (6):

Pancuronium (I)


As an adjunct to general anesthesia; to induce skeletal muscle relaxation; to reduce the intensity of muscle contractions in electroconvulsive therapy; to facilitate the care of patients undergoing mechanical ventilation


Pancuronium (A)

Occupies the muscular cholinergic receptor site, preventing ACh from reacting with the receptor; does not cause activation of muscle cells; causes a flaccid paralysis


Pancuronium (AE-CI-DD)

AE- Respiratory depression, apnea, cardiac arrhythmias
CI- myasthenia gravis, renal or hepatic disease, family history of malignant hyperthermia, caution w/ pulmonary or cardiovascular dysfunction, alter electrolyte and fluid imbalance, lactation
DDI- halogenated hydrocarbon anesthetics, Calcium-Channel blockers, xanthines, and alkaline solutions such as barbiturates, cholinesterase inhibitor


Succinylcholine (I)


As an adjunct to general anesthesia; to facilitate endotracheal intubation; to induce skeletal muscle relaxation during surgery or mechanical ventilation


Succinylcholine (A)

Combines with ACh receptors at the motor endplate to produce depolarization; this inhibits neuromuscular transmission, causing a flaccid paralysis


Succinylcholine (CI)

fractures, narrow angle glaucoma or penetrating eye injuries, genetic or disease-related conditions, low plasma cholinesterase.