Chapter 25 - Muscle Relaxants Flashcards Preview

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Flashcards in Chapter 25 - Muscle Relaxants Deck (5):
1

Baclofen (I-A)

Central Acting

Indi- Alleviation of signs and symptoms of spasticity, may be use in spinal cord injuries or spinal cord disease

Action- Gamma aminobutyric acid analogue, exact mechanism of action is not understood, inhibits monosynaptic and polysynaptic spinal reflexes, CNS depressant

2

Baclofen (AE-CI-DD)

AE- Transient drowsiness, insomnia

CI- allergy, skeletal muscle spasms resulting from rheumatic disorders, history of epilepsy, cardiac dysfunction, muscle weakness, hepatic and renal dysfunction and prego/lact

DI- alcohol

3

Dantrolene (I)

Direct Acting

Control of clinical spasticity resulting from upper motor neuron disorder, preoperatively to prevent or attenuate the development of malignant hyperthermia in susceptible patients, IV for management of fulminant malignant hyperthermia

4

Dantrolene (A)

Interferes with the release of calcium from the sarcoplasmic reticulum within skeletal muscles, preventing muscle contraction; does not interfere with neuromuscular transmission

5

Dantrolene (AE-CI-DD)

AE- Hepatitis, myalgia, BP changes
CI- allergy, spasticity that contributes to locomotions, upright position, or increase function, active hepatic disease, infection at injection site
DI- combined with estrogen