Flashcards in Chapter 24 - AntiParkinsonism Agents Deck (6):
Treatment of Parkinson’s disease
Precursor of dopamine, which is deficient in Parkinsonism; crosses the blood-brain barrier, where it is converted to dopamine and acts as a replacement neurotransmitter; effective for 2 to 5 years in relieving the symptoms of Parkinson’s disease.
AE- Adventitious movements, ataxia, agitation, cardiac irregularities
CI- angel-closure glaucoma, history or presence of suspicious skin lesions, cautiously use w/: MI, arrhythmias, HTN, brachial asthma, peptic ulcers, Urinary tract obstruction and psychiatric disorders
DDI- MAOI SHOULD BE STOPED 14 days before starting on dopaminergic and no OTC drugs
Indi- Adjunctive therapy for Parkinson’s disease, relief of symptoms of extrapyramidal disorders (parkinsonism) that accompany neuroleptic therapy
Actions- Acts as an anticholinergic, principally in the CNS, returning balance to the basal ganglia and reducing the severity of rigidity, akinesia, and tremors; peripheral anticholinergic effects help to reduce drooling and other secondary effects of parkinsonism