Chapter 22 - Psychotherapeutic Agents Flashcards Preview

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Flashcards in Chapter 22 - Psychotherapeutic Agents Deck (12):

Chlorpromazine (I)

Typical Antipsychotics

Management of...
Manifestations of psychotic disorders
Relief of preoperative restlessness
Adj treatment of tetanus
acute intermittent porphyria
Severe behavioral problems in children
Control of hiccups N/V


Chlorpromazine (A)

Blocks synaptic dopamine receptors in the brain, depresses those parts of the brain involved in wakefulness and emesis, anticholinergic, antihistaminic, alpha-adrenergic blocking.


Chlorpromazine (AE)

Extrapyramidal symptoms
Ortho hypoTN


Chlorpromazine (CI-DD)

CI: CNS depression, circulatory collapse, Parkinson's, coronary disease, patients experience increased CV events and death. children younger than 12 years of age.

DD: Beta blockers
Other antipsychotic agents (^anticholinergic)


Clozapine (I)

Management of severely ill patients with schizophrenia who are unresponsive to standard drugs; reduction of risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder.

Blocks dopamine and serotonin receptors, depresses the RAS, anticholinergic, antihistaminic, alpha-adrenergic blocking.


Clozapine (AE)

Headache, neuroleptic malignant syndrome, syncope


Lithium (I) (A)

I: Treatment of manic episodes of bipolar, manic depressive illness.
A: Alter sodium transport in nerve and muscle cells; inhibits the release of norepinephrine and dopamine, but not serotonin, from stimulated neurons; increases the intraneuronal stores of norepinephrine and dopamine slightly; and decreases the intraneuronal contents of second messengers.


Lithium (AE)

Central nervous system problems, including with RG, slurred speech cardiovascular collapse, coma,


Lithium (CI-DD)

CI: significant renal or cardiac disease, Leukemia, Dehydration, diuretic use, Sodium depletion, suicidal or impulsive pt, Infection with fever

DD: thiazides increase lithium toxicity cus of loss of sodium
antacids (v effect of lithium)


Methylphenidate (I-A)

CNS stimulants

I: narcolepsy and attention deficit disorder
A: mild cortical stimulation with central nervous system actions similar to those of amphetamines


Methylphenidate (AE)

Increased or decreased pulse rate and blood pressure, Loss of appetite


Methylphenidate (CI-DD)

CI: marked anxiety, agitation or tension, glaucoma, cardiac disease, drug dependence including alcoholism

DD: MAO inhibitor leads to an increased risk of Adverse effects an increased toxicity; CNS stimulant w/ tricyclic antidepressants