Chapter 23 - Antiseizure Agents Flashcards Preview

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Flashcards in Chapter 23 - Antiseizure Agents Deck (18):
1

Phenytoin (I)

Hydantoins

Control of tonic-clonic and psycho motor seizures, prevention of seizures during neurosurgery, Control of status epilepticus.

2

Phenytoin (A)

Stabilizes neuronal membranes and prevents hyperexcitability caused by excessive stimulation; limits the spread of seizure activity from an active focus; has cardiac antiarrhythmic effects similar to those of lidocaine.

3

Phenytoin (AE)

nystagmus
ataxia
dysarthia
stevens johnson syndrome
gingival hyperplasia
sometimes fatal

4

Phenytoin (CI-DD)

CI: Discontinuing may lead to status epilepticus
women wear condoms pls
elderly
hepatic impairment *

DD: alcohol

5

Phenobarbital (I)

Barbiturates

Long term treatment of tonic-clonic and cortical focused seizures, emergency control of certain acute convulsive episodes and anticonvulsant treatment of generalized tonic clonic seizures and focal seizures (parenteral).

6

Phenobarbital (A)

General CNS depressant inhibits impulse conduction in the ascending RAS depresses the cerebral cortex alters cerebellar function depresses motor output and can produce excitation, sedation, hypnosis, Anesthesia, and deep coma.

7

Phenobarbital (AE)

somnolence
nightmares
hallucinations
respiratory depression
tissue necrosis at site
withdrawal syndrome

8

Phenobarbital
Diazepam
(CI-DD)

CI: same as hydantoins

DD: Alcohol

9

Diazepam (I)

Benzodiazepine

management of anxiety disorders acute alcohol withdrawal; Muscle relaxing, Treatment of tetanus, Adj. in status epilepticus and severe recurrent convulsive seizures, Preoperative relief of anxiety and tension, management of epilepsy and patients require intermittent use to control increased seizure activity

10

Diazepam (A)

Acts in the limbic system and reticular formation, potentiates the effects of GABA, has little effect on cortical function.

11

Diazepam (AE)

Apathy
Paradoxical excitatory reactions
drug dependence
withdrawal syndrome

12

Ethosuximide (I-A)

Succinimide

I: Control of absence seizures
A: may act in inhibitory neuronal systems suppresses the electroencephalographic pattern associated with absence seizures, reduces frequency of attacks.

13

Ethosuximide (AE)

Stevens Johnson syndrome
pancytopenia
irritability

14

Ethosuximide (CI-DD)

CI: Intermittent porphyria
DD: none

15

Carbamazepine (I)

Partial Seizure Drugs

Treatment of seizure disorders including partial seizures with complex patterns; tonic clonic seizures; Mixed seizures; trigeminal neuralgia.

16

Carbamazepine (A)

Inhibits polysynaptic responses and blocks posttetanic potentiations; mechanism of action is not understood; related to tricyclic antidepressants.

17

Carbamazepine (AE)

CV complications
Hematological disorders
Stevens-Johnson syndrome

18

Carbamazepine (CI-DD)

CI: Pregnancy, women pls use condoms.
DD: CNS depressants/alchohol
Hormonal contraceptives