anti-RA drugs Flashcards Preview

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Flashcards in anti-RA drugs Deck (36):
1

problem with using NSAIDS for RA

do not prevent the irreversable damage to the joints

2

problems with using corticosteroids for RA

too many side effects with long term use

3

current use of steroids in RA

bridge therapy until long-term drugs kick in

4

synthetic RA DMARDs

methotrexate, hydrocychloriquine, sulfalazine, lefunomide, gold salts

5

biological RA DMARDS

TNF inhibitors, IL-1 inhibitors, IL-6 inhinitors, B/T cell inhibitors

6

SE of methotrexte

hepatotox

7

SE of sulfasalazine

hepatotox

8

SE of antimalarial drugs

retinopathy

9

MOA of methotrexate

antimetaboliite (inhibits DHF)

10

MOA of sulfasalazine

anti-inflammatory and antimicrobial

11

MOA f cyclosporin

T-cell avtivation inhibitor

12

SE of cyclosporin

kidney tox

13

use of sulfasalzine

RA, juvinile chronic arthritis, ankylosing spondy

14

typically added to pts taking methotrexate

leflunomide

15

may increase hypertension

leflunomide

16

TNF inhibors

etanercept, xxx-mab (NOT tocilizumab/rituximab)

17

increases risk of infection, ESPECIALLY TB

TNF inhibitors

18

can cause MS-like illness

TNF inhibitors

19

black box warning about cancer risk

TNF inhibitors

20

must screen for TB before using

TNF inhibitors

21

chimeric human/mouse monoclonal anti0TNF anibody

infliximab

22

T/B cell inhibitors

anakinra, tocilizumab, abatacept, , rituximab, tofiacitnib,

23

anti IL-6 drug

tocilizumab

24

used when other DMARBs fail

tocilizumab, rituximab

25

cannot be used with TNF-inhibitors

tocilizumab, abatacept, ritiximab, tofacitinab

26

prevents T-cell activation

abacept

27

binds to CD20 on B cells to cause depletion

rituximab

28

inhibitor of JAX

tofacitnib

29

contraindications tofacitinib

pregnancy, liver disease or hematologic abnormalities

30

last resort drug not to be used in kids

cyclophosphamide

31

nephrotixic last resort drug

cyclosporine

32

immunosuppressive purine analige

azathippurine

33

last resport drug causing hepatotixicty, GI tox, bone marrow supression

azathiopurine

34

general combo therapies (2)

DMARD + NSAID or steroid (gradulally wd NSAID/steroid)

in non responders add lefulonomide or TNF inhibitor to methotrexate

35

drugs to use in combo therapy if TNF inhibitors fail

IL-1/6 or B'/t cell inhibotors

36

drug to remove with gold salts/last resort agents

methotrexate