bone and soft tissue non-neoplastic Flashcards Preview

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Flashcards in bone and soft tissue non-neoplastic Deck (24):
1

major cause of dwarfism

achondroplasia

2

mutation in achondroplasia

FGFR3

3

problem in achondroplasia

FGFR3 mutation normally inhibits cartilage proliferation. Mutation turns it on permantly, causing it to prevent chondrocytes from bein formed

4

collegen deficiancy in osteogenesis imperfecta (OI)

type 1

5

blue schlera found in

OI

6

condition where bones are harder than usual

osteopetrosis

7

deficency in osteopetrosis

carbonic anhydrase II, which stimulates osetoclast activity

8

causes of osteoporosis

being female, being old, low Ca intake, low exersize, decreasin estrogen levels

9

why don't men get osteoporosis?

testosterone

10

fracture sites in osteoporosis

femoral neck and vertabrae

11

test for osteoporosis

DEXA bone scan

12

abnormal bone matrix due to excessive remodelling

paget's disease

13

phases of paget's disease

osteolytic, mixed osteoclastic/osteoblastic, quiescent osteoschlerotic

14

"My hats don't fit!"

paget's disease

15

complications of paget's disease

deafness, bone neoplasms

16

rib nodules and bowleggedness

osteomalcia

17

issue in osteomalacia

decreased bone mineralization

18

how to tell the difference between neoplams of PTH clands and hyperplasia

neoplasm will be in only one gland

19

organ failure that can lead to secondary hyperparathyroidism

kidney

20

brown tumors lead from

hyperPTHism

21

drugs that can cause osteonecrosis

corticosteroids

22

bug that causes pyoenic osteomyeltis, normally

staph A

23

bug that causes pyoenic osteomyeltis in iv drug use of secondary to GU infections

e coli, pseudomonas, klebsiela

24

bug that can cause osteomyelitis in sickle cell pts

salmonella