Measles and such Flashcards Preview

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Flashcards in Measles and such Deck (60):
1

morphology of measles virus

enveloped, negative sense, single stranded RNA virus with 6 structural proteins

2

location of measles replication

cytoplasm

3

giant cells indicitve of

measles

4

transmisson of measles

respiratory droplets

5

tract of infection of measles

resp tract --> lymphatics --> spleen --> blood stream

6

measles virus infects what tissues

all epithelial cell surfaces

7

abrupts onset of illness with cough, coryza, rhinorrhea, photophobia, and conjuctivitis

measles

8

lesions on buccal mucosa with red halo (koplik's spots)

measles

9

koplik spots precede measles rash how long?

12-24 hours

10

maculopapular lesions

measles

11

sickest day of measles

day rash appears

12

causes measles rash

T-cell response to measles virus antigens in endothelial cells of skin capillaries

13

measles complications

giant cell pneumonia
encephalitis
SSPE
atypical measles
secondary bacterial pneumoia

14

fatal , non rash measles complication in people with defective cell mediated immunity

giant cell pneummonia

15

CNS issue, myoclonic jerks, photophobia, blindness, coma 6-15 years after measles infection

SSPE

16

conplication form killed measles virus

atypical measles

17

where you can grow measles virus

monkey kidneys or human cell cultures

18

easiest and efficient way to confirm measles

immunoflouracense assay for in cells harvested from mucus, urine, and skin biopsies

19

giant cells on giemsa stain

measles

20

treatment for early exposure to measles

pooled immunolobulin or vaccination witin 2/3 days of exposure

21

acute, painful parotitis

mumps

22

paramyxoviruses

measles/mumps

23

out of respiratory sites of mumps

testes, meningies, pancreas and ovaries

24

where you can row mumps virus

monkey kidneys

25

multinucleated giant cells

mumps

26

sites of recovering mumps virus from pts

saliva, urine, pharynx, secrections from Stensen's duct, and CSF

27

1/3 of infections are subclinical

mumps

28

can cause congenital defects in infected pregnant mothers

rubella

29

togavirus

rubella

30

envoloped, positive sense, single stranded RNA virus with icosahedral nucleocapsid

rubella

31

ranges from inapparent infection to lymphedenopathy, mild malaise, corzya, low-grade fever and rash

rubella

32

irregular pink, maculopapular lesions starting on the face, spreading to the trunk and lasting 3 days

rubella

33

adult femals with polyarthritis and polyarthalgia

rubella

34

diagnosis of rubella

specific IgM antibody (in green monkey kidneys)

35

reinfection can occur in immune folks

rubella

36

vaccination contraindicated in pregnant women

rubella

37

time in pregnancy most vunreable to congenital rubella infection

first 20 weeks

38

baby sx of congenital rubella

cararacts, MR, deafness, heart defects, microcephaly, and rash

39

"bluberry muffin baby"

congenital rubella

40

place to detect rubella virus in baby

CSF, urine, rectal swab

41

serodiagnostic of in utero infection of rubella

IgM in cord serum

42

time kids born with CRS should be considered infectious

1 year

43

icosahedral visur with no capsid

B19 parvoviruses

44

fifth disease virus type

B19 parovirus

45

pathenogenisis of congenital rubella

affects normal growth, mitosis, and chromosomal structure in cells

46

distinct non vesicular rash on cheeks, resembing a slap with polyarthritis,

fifth disease

47

can cause aplastic crisis

fifth disease

48

fatal parvovirus infection in fetus

hydrops fetalis

49

virus that spreads to bone marrow

B19 parovirus

50

dianosis of b19 parvovorus

IgM or viral DNA by PCR

51

big-ass 2x stranded DNA virus

pox

52

reolicates it;s genome and assembles virons in cell cytoplams with large cytoplasmic inclusions

pox

53

difference between pox viruses and chickenpox

all skin lesions are the same stage in development in pox diseases

54

variola causes

smallpox

55

vaccina casues

cowpox

56

replication site of pox

upper resp tract

57

western/central africa pox virus

monkey pox

58

sheep pox that can be transmitted to humans

orf virus

59

clusters of wart lije viruses on the face

molluscum contagiosum

60

diagnostic for molluscum contagiosum

large cytoplasmic inclusions