inflammatory dermopathies Flashcards Preview

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Flashcards in inflammatory dermopathies Deck (60):
1

hereditary angioedema caused by

inherited deficency of C1 esterase inhibitor

2

localized mast cell degranulation leads to...

dermal microvascular hyperpermeability (urticaria)

3

red papules, with overlapping vesicles that ooze and become encrusted

acute excematous dermatitis (eczema)

4

epidermal edema also known as

spongiosis

5

immune presenting cells in skin

langerhans cells

6

condition where fluid seeps into the epidermis, splaying apaty keratinocytes

spongiotic dermatitis

7

hypersensitivity reaction to certain infections and drugs

erythema multiforme

8

infections that can cause erythema multiforme

herpes simplex, some mycoplasms and fungi

9

drugs that can cause erythema multiforme

sulfaonamides, penicillin, salicytes, hydantoins, antimalarials

10

wide diversity of lesions including macules, papules, vesicles and bullae with target lookin lesions

erythema multiforme

11

erythema multiforme pathenogenisis

skin-homing cytotoxic T cells attackin basal cells of the skin and mucosa

12

superfical perivascular lymphocytic infiltrate with epidermal edema abd degenerating keratinocytes

erythema multiforme

13

severe form of erythema multiforme

toxic epidermal necrolysis

14

complications of psorisis

heart attacks and stokes, arthritis

15

koebner phenomenon

psoroatic lesions brought on by trauma

16

cells mediating psorias reactions

T cells inducing keratinocyte hyperproliferation

17

well-demarcated pink to salmon colored plaque covered by looseky adherend silver-white scale

psorisis

18

rete ridges "test tubes in a rack"

psorisis

19

auspitz sign

multiple bleeding sites in psorisis

20

casues scaleing in psorisis

loss of stratum granulosum and extensive parakeratotic scale

21

treatment of psorisis

NSAIDS, cyclosporin, TNF antagonosts

22

puritic, ciolaceousm flat topped papules highlighted with white dots or lines

lichen planus

23

lesions concentrated at interface of sqaumous epithelium and papillary sermis

interface dermatitis

24

microscopic "sawtoothing" abd civatte bodies

lichen planus

25

symmettic lesions on wrists, elbows, glans penis and often in the mouth

lichen planus

26

acanthosis, hyperkeratosis and hypergranulosis

lichen simplex chronicus

27

lesions that look like normal palm/dorsum of foot thckening

lichen simplex chronicus

28

protiens attacked in pemphigus diseases

demmoglein

29

type of hypersensitivity reaction in pemphius diseases

II

30

immunoglobulin attacking in pemphigus diseases

IgG

31

"fishnet pattern" on immunoflourecence

pemphigus vulgaris

32

superficial flaccid vesicles and bullae that rupture easily leaving extensive erosions and crust

pemphigus vulgaris

33

pemphigus disease that attacks mucosa and skin

pemphigus vulgaris

34

lysis of the intercellular adhesive junctions between neihboring squamous epithelial cells

acantholysis

35

detachment involves the cells immediatly ABOVE the basal layer

pemphigus vulgaris

36

pemphigus disease that mostly strikes elderly women and has oropharnygeal involvement

pemphigus vulgaris

37

site of attack in bullous pemphigus

hemidesmosomes

38

linear immunoflourecense in subepidermal basement membrane zone

bullous pemphigus

39

tense, fluid-filled blisters

bullous pemphigus

40

subepidermal nonacantholytic blisters

bullous pemphigus

41

full thickness epidermal blisters

bullous pemphigus

42

blisters do not rupture as easily

bullous pemphigus

43

extremly prurtic urticaria and grouped vesicles

dermatitis herpetiformis

44

strong association with celiac disease

dermatitis herpetiformis

45

granular deposits of IgA at tips of dermal papillae

dermatitis herpetiformis

46

Stevens-Johnson syndrome

severe form of erythema multiforme

47

causes Stevens-Johnson syndrome

sulfanomnides

48

severe form of Stevens Johnson syndrome

toxic epidermal necolysis

49

nikolsky sign

rubbing of skin produces blister (toxic epidermal necolysis)

50

pitting of fingernails

psoriasis

51

psoriasis associated with

arthritis, mypopathy, enteropathy, AIDS, CV disease, depression

52

malar erythema, worse in sun exposed skin,

lupus erythematosus

53

superficial and deep perivascular lyphocytic infiltrate with inflammation around hair follicles and sweat glands

lupus erythematosus

54

IgG against desmosomes

pemphius vulgaris

55

antibodies to gluten

demratiis herpetiformis

56

non0inflammatory acral blisters that heal with scar

epidermolysis bullosa aquisista

57

antibodies to collagen VII

epidermolysis bullosa aquisista

58

paucicellular subepidermal blister

epidermolysis bullosa aquisista

59

immunoflorecent line between epidermis and dermis

epidermolysis bullosa aquisista

60

collagen vascular diseases associated with

erythema multoforma