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Flashcards in path intro to skin Deck (36):
1

flat, circumscribed lesion < 0.5 cm

macule

2

flat, circumscribed lesion > 0.5 cm

patch

3

elevated dome-shaped or flat topped lesion < 0.5 cm

papule

4

elevated solid area > 0.5 cm

nodule

5

elevated flat-topped area usually > 0.5 cm

plaque

6

fluid filled raised area < 0.5 cm

vesicle

7

fluid filled raised area > .5 cm

bullae

8

discrete, pus filled area

pustule

9

transient, pritic, erythematosus lesion often pink with whitish center

wheal

10

cause of wheals

edema

11

dry, flaky area on skin

scale

12

thickened and rough skin with proninent skin markings

lichenifcation

13

traumatic lesion with epidermal disruption

excoriation

14

hyperplasia of stratum corneum

hyperkeratosis

15

kertinization pattern with retentio of nuclei in stratum corneum

parakeratosis

16

epidermal hyperplasia

acanthosis

17

abnormal keratinaztion

dyskeratosis

18

loss of intercellular connections in epidermis

acantholysis

19

increased intercellularedema in epidermis

spongiosos

20

incomplete loss of epidermis

erosion

21

complete loss of epidermis

ulceration

22

origin of melanocytes

neural crest

23

patchy loss of melanocytes due to antibodies to them

vitiligo

24

defect in melanin synthesis

albanism

25

small tan-red or lih brown macle

ephelis (freckle)

26

local slight hyperplasia of melanocytes

lentigo

27

"mole" term

nevocellular nevus

28

composed of melocytes that have lost dendritic processes

nevocellularnevus

29

nevus with increased risk of melaoma transformation

giant congenital nevus

30

sites of melanoma

skin, oral mucose, anogenital mucosa, esophagus, meinges, eye

31

major risk factors for melanoma

past hx of melanoma
brief, intermittent, intesne UV exposure between 10-24 years of age
xeroderma pigmentosa

32

familial melanoma gene

CDKN2A on 9p21

33

sporadic melanoma gene

BRAF, PTEN, p16

34

when to suspect a mole maybe a melanoma

asymmatry
border irregularity
multicolored
diameter > 6 mm
any change

35

metastatic potential of melanoma related to...

depth of the tumor

36

most important prognistic indicator of melanoma

sentiniel lymph node