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Flashcards in Bacterial Infection 1 Deck (52):
1

morphology of bacililus

gram + spore formiong bacilli

2

types of anthrax infection

cutaneous, GI, pulmonary

3

industry associated with most anthrax infections

textile

4

animals most often infected with anthrax

sheep, then cattle

5

most common type of human anthrax infection

cutaneous

6

decribe anthrax skin presentation

painless pruritic papule that vesiculates and ulcerates with draining of a blackish exudate

7

GI presentation of anthrax

n/v, and fever progrssing to hemorragic vomiting abdominal pain and shock

8

mortality of GI anthrax

50%

9

mortality of skin anthrax

20% untreated

10

mortality of inhaled anthrax

>80%

11

name the plasmid encoding anthrax toxins

pXO1

12

3 anthrax toxins

protective antigen, edema factor, and lethal factor

13

A-B anthrax toxins

edema and lethal

14

forms the lethal toxin

protctive antigen and lethal factor

15

forms the edema toxin

protective antigen and edema factor

16

anthrax factor that is an adenylate cyclase

edema factor

17

activates edema factor

intracellular calmodulin and Ca++

18

MOA of lethal factorq

cleaves MAPKK inside macrophages. inhibits signal transduction leading to cell death

19

makeup of anthrax protien capsule

poly-D glutamic acid

20

plasmid encoding anthrax capsule

pXO2

21

regulates transcription of anthrax toxin and capsule

body temp and CO2

22

DOC for anthrasx

penicillin/Cipro.doxy

23

prevention of anthrax

vaccination of livestock, burying of unbroken cattle carcasses

24

genus of plauge

yersinia

25

morphology of yersinia

gram - rods, looking like safety pins

26

virulence factors for yersiniae

adhesin, Yop proteins, low calcium rtesponse V antigen, hemin storage factor

27

proteins injected into the host cell by yersiniae

Yop

28

MOA of Yop proteins

interfere with phagocytosis, detroying filaments and inhibiting platelet aggregation of eukaryotic cells

29

promotes Y pestis colonization in flea proventriculus

Hms

30

y pestis virulence factor that suppresses host immune response

LcrV

31

pandemic plague

urban

32

sporadic plague

sylvatic

33

resivoir for yersini pestis

rat

34

vector for plague

rat flea

35

way fleas transnit plague

vomiting infected blood from infected host into wound of new host

36

highest mortality plague

pnemonic

37

clinical types of plague

pnemonic and bubonic

38

culture mediums of plague

blood/maconcky agar

39

DOC for plague

streptomyocin

40

morpholoy of f tularensis

very small gm - coccobacillus

41

virulance factor in tularensis

capsule and endotoxin

42

resivoir of tuleramia

rabbits and small mammals

43

vector of tuleremia

ticks and deer flies

44

main range of tuleramia

arkansas/missouri

45

most virulent type of tuleramia

type A

46

number of tulerima bacteria that can make you sick if inhaled

10

47

pathogenesis of tulermia

infects organs rish with fixed tossue macrophages causing granulomas and necrosis

48

way tulermia survives macrophages

inhibits phagsome lysosome function

49

most common form of tuleramia

ulceroglandular

50

sx of ulceroglandular tulermia

local papule forms at site of inculation and becomes painful and ulcerative. Mat involve regional lymph nodes

51

media crowing tuleremia

cystein supplemented chocolate agar

52

DOC of tuleremia

streptomycin. possible gentamicin, fluroquinolones, and doxy