Anti-TB Agents Flashcards Preview

RESP II Exam 2 > Anti-TB Agents > Flashcards

Flashcards in Anti-TB Agents Deck (30):
1

first line TB agents

isoniazid, rifampin, pyrazinamide, ethamobutol, streptomycin

2

most active drug against TB

isoniazid

3

isoniazid MOA

inhibits synthesis of mycolic acids (mycobacterial cell wall)

covalent complex with AcpM and KasA

4

resistance with isoniazid

overexpress inhA
mutation of katG
overexpress ahpC
mutation kasA

5

adverse with INH

hepatitis - major toxic effect

peripheral neuropathy - B6 deficiency

6

vit B6 deficiency

pyridoxine

with isoniazid tx

peripheral INH

7

rifampin MOA

binds to beta-subunit of bacterial DNA-dependent RNA polymerase and inhibits RNA synthesis

bacteriacidal for mycobacterium

8

resistance in rifampin

mutation of rpoB

9

P450 inducer

rifampin
-may alter HIV NNRTI treatment

10

red/orange urine color

rifampin

11

pyrazinamide

MOA unknown
-active at pH 5.5

converted to pyrazinoic acid in macrophages

12

pyrazinamide resistance

mutation of pncA

13

most hepatotoxic first line agent

pyrazinamide

14

ethambutol MOA

inhibit mycobacterial arabinosyl transferase - encoded by embCAB operon

involved in polymerization rxn of arabinoglycan - component of mycobacterial cell wall

15

arabinoglycan

ethambutol inhibits this

16

ethambutol resistance

overexpress emb gene
mutation of embB gene

17

streptomycin

aminoglycoside

IM/IV administer

18

streptomycin MOA

irreversible inhibitor of protein synthesis

binds S12 of 30S subunit

19

streptomycin resistance

mutations in rspL gene or rrs gene

20

streptomycin scope

mycobacterium tuberculosis
mycobacterium avium complex
mycobacterium kansasii

21

vertical nystagmus

ethambutol

22

vertigo and hearing loss

streptomycin

23

severe/life-threatening TB

streptomycin

administered IV

24

ethionamide

isoniazid second-line

25

rifabutin
rifapentine

rifampin second-line

26

amikacin
capremoycin
kanamycin

streptomycin second line

27

leprosy drugs

clofazimine
dapsone

28

four drug regimen

administered until susceptibility is determined

done bc drug resistant mutants are very frequent in population

29

hepatotoxic drugs

INH, rifampin, pyrazinamide

pyrazinamide is most hepatotoxic

should be stopped - serum aminotransferase reaches 5x upper limit

30

N-acetyltransferase

polymorphism at NAT2 cause variation in rate of acetylation

slow vs. fast acetylators

isoniazid biotransformation