Flashcards in Interstitial Lung Disease DSA II Deck (50)
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1
churg strauss syndrome
systemic necrotizing vasculitis
-upper and lower resp tracts
preceded by allergic disorders
peripheral and lung eosinophilia
IgE increase
rashes
2
CXR for churg strauss
bilateral patchy, fleeting infiltrates
diffuse nodular infiltrates
diffuse reticulonodular infiltrates
3
biopsy for churg strauss
granulomatous angiitis or vasculitis
4
Tx for churg strauss
corticosteroids
5
chronic eosinophilic pneumonia
pulmonary interstitium and alveolar spaces are infiltrated by eosinos and to lesser extent macrophages
6
clinical for chronic eosinophilic pneomonia
over weeks to months
-fever, weight loss, dyspnea, productive cough
pulmonary infiltrates with peripheral distribution
increased eosinophils in peripheral smear
BAL with increased eosinophils
7
Tx of chronic eosinophilic pneumonia
dramatic response to corticosteroids within days to weeks
therapy - prolonged for months - prevent recurrence
8
pulmonary alveolar proteinosis
primary path process affects alveolar spaces
filled with proteinacious phospholipid material
-components of surfactant
9
clinical for pulmonary alveolar proteinosis
dyspnea, cough, bilateral alveolar infiltrates
10
high res CT for pulmonary alveolar proteinosis
crazy paving pattern
thickened interlobular septa accompanied by groundglass alveolar filling
11
nocardia
superimposed resp infection
with pulmonary alveolar proteinosis
12
Tx for pulmonary alveolar proteinosis
whole lung lavage
good prognosis
13
whole lung lavage
gold standard treatment for pulmonary alveolar proteinosis
-saline into lungs with percussion to dislodge material in lungs
fluid then removed
repeated until no more material is recovered (when fluid is clear)
14
hypersensitivity pneumonitis
hyperimmune respiratory syndrome caused by inhalation of wide variety of allergic antigens that are usually rganic
bacteria, fungi, protozoa, animal proteins, reactive chemicals
15
Tx for hypersensitivity pneumonitis
avoid exposure
corticosteroids speed resolution
16
intermittent pulmonary and systemic symptoms, progressive interstitial CXR changes, non-resolving pneumonia
suspect hypersensitivity pneumonitis
agriculture, cattle farming, bird keeping, contaminated home ventilation, hot tubs
17
abrupt onset of cough, dyspnea, fever, chest pain, following heavy exposure to offending antigen, Sx 4-6 hours after exposure
subsides 24 hours after removal from exposure
acute hypersensitivity pneumonitis
18
gradula development of symptoms and less severe intensity
subacute hypersensitivity pneumonitis
19
insidious progressive dyspnea, cough, weight loss, fatigue, pulmonary fibrosis and resp failure
chronic hypersensitivity pneumonitis
20
thermophilic actinomycetes
moldy hay, grain, silage - farming - dairy cattle
hypersensitivity pneumonitis
also from ventilation - water-related contamination
-humidifier, hot tub, air conditioner
21
mycobacterium avium intracellular complex
hypersensitivity pneumonitis
from ventilation and water-related contamination
22
CXR for hypersensitivity pneumonitis
acute disease
-diffuse reticulonodular infiltrates
chronic disease
-diffuse interstitial fibrosis
23
high res CT for hypersensitivity pneumonitis
ground glass opacities early
chronic - with traction bronchiectasis, honeycombing, and fibrosis
24
PFT for hypersensitivity pneumonitis
restrictive, small lung volume, decreased diffusion capacity
25
sarcoidosis
systemic granulomatous disease
-non-caseating granuloma
can effect any organ
unknown etiology
age 40-60yo
-peak 20-40yo
3.5x higher than african americans
more in women
26
sarcoidosis
pulmonary not necessary for Dx
abnormal CXR with mediastinal and hilar adenopathy
may lead to chronic disease
-pulmonary fibrosis
27
lofgrens syndrome
acute manifestation of sarcoidosis
-erthyema nodosum
-arthritis
-bilateral hilar lymphadenopathy
favorable prognosis
28
fatigue, night sweats, fever, weight loss, cough, dyspnea, wheeze, rash, macules, hyper/hypopigmentation, erythema nodosum, dry eyes, pain, redness, blurry vision, arrhythmia, palpitations, syncope, HAs, numbness, epigastric pain, RUQ pain, jaundice, swelling and joint stiff, muscle pain, nasal congestion, sinus pressure
sarcoidosis
29
rales, exp whezing, infiltration of old scars/tattoos, macolopapular lesions, erythema nodosum uveitis, iritis, scleral plaque, irregular cardiac rhythm, CN II, VII, VIII neuropathies, hepatomegaly, arthritis, palpable adenopathy
sarcoidosis
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