Asthma DSA Flashcards Preview

RESP II Exam 2 > Asthma DSA > Flashcards

Flashcards in Asthma DSA Deck (23):
1

definition of asthma

3 components

1 recurrent airway obstruction - resolves with treatment
2 airway hyper-responsiveness, exaggerated bronchoconstriction in response to stimuli with little or no effect on non-asthmatic patients
3 airway inflammation

2

asthma populations

8% adults
boys more than girls
before age 25 common

3

mild asthma

edema and hyperemia of mucosa plus mucosal infiltration with mast cells, eosionphils, and lymphocytes

4

moderate asthma

chemokines eotaxin, RANTES, macrophage inflammatory protein 1 alpha, IL 8 lead to inflammation and smooth m consriction

5

severe asthma

hypertrophy and hyperplasia of airway glands and smooth m lead to severe airway thickening

6

airway obstruction causes

1 constriction of airway smooth m
2 thickened airway epithelium
3 liquids in airway

7

ACh

stimulate M3 muscarinics - causing smooth m constriction

8

histamine

released from mast cells

9

leukotrienes and lipoxins

derived by lipoxygenation of arachidonic acid released from target cell membrane phospholipids during cell activation

10

nitric oxide

produced by airway epithelium and by inflammatory cells found in asthmatic lung
-high levels found during asthma attack**

11

mild intermittent asthma

symptoms for < 2 days / week or < 2 nights / week

12

mild persistent asthma

symptoms > 2 days / week but < 1 daily, or > 2 nights / month

13

moderate persistent asthma

symptoms daily or > 1/night

14

severe persistent asthma

symptoms continual during day or frequent at night

15

tachypnea, tachycardia, pulsus paradoxus, accessory muscle use, hyperinflamtion, prolonged FEV1, expiratory wheezing

asthma

16

asthma ABG

often hypocapnea

if normalizes- may indicate resp failure

17

asthma CBC

eosinophilia, elevated IgE

18

asthma EKG

sinus tachycardia, RBBB, P pulmonale, ST-T changes

19

intermittent asthma Tx

short acting beta2 agonist

20

mild persistent asthma Tx

short acting beta2 agonist

inhaled corticosteroid

alternate - mast cell stabilizer, leukotriene-receptor antagonist, theophylline

21

moderate persistent asthma Tx

short acting beta2 agonist

low-medium dose corticosteroid

long acting beta2 agonist

alternate - inhaled corticosteroids and leukotriene antagonist or theophylline

22

severe persistent asthma Tx

short acting beta2 agonist PRN

high dose inhaled corticosteroid and long acting beta2 agonist

if severe - prednisone

23

omalizumab

monoclonal antibody for IgE

moderate to severe persistent asthma with reactivity to allergen and who inhaled corticosteroid Tx does not work