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RESP II Exam 2 > Immunology > Flashcards

Flashcards in Immunology Deck (22):
1

host defense in alveolar spaces

alveolar macrophages

Igs, opsonins, surfactants, lymphocyte mediated immunity, neutros and eosinos

2

sarcoidosis

increased lymphocytes

CD4 alveolitis

3

interstitial lung disease in smoker

carbonacesous macrophage

4

scleroderma

systemic sclerosis

neutrophils
eosinophils

5

idiopathic pulmonary fibrosis tx

corticosteroids not indicated

6

nonspecfic interstitial pneumonia tx

favorable response to corticosteroids

7

protective against radiation induced lung fibrosis

ACE

8

increased fibrosis

IGFBP5

9

increased fibroblast activity

endothelin 1
angiotensin II

10

anti-imflammatory and tissue repair promotion

TGF-beta

anti-proliferative
-promote epithelial mesenchymal transition

chronic expression - tissue fibrosis

11

source of TGF beta

alveolar macrophages in idiopathic pulmonary fibrosis

12

genetics of IPF

surfactant protein A2 and C

telomerase

MUC5B

13

systemic sarcoidosis

multisystem granulomatous

noncaseating epitheliod granulomas

depression of DTH response

14

sarcoidosis inflammatory response

TNF-alpha
IL-7
MMP-12

15

hypersensitivity pneumonitis immune response

higher in non-smokers**

lymphocytes, neutrophils, degranulated macrophages

16

hypersensitivity pneumonitis tx

corticosteroids aids recovery initially, long term outcome is unaffected

17

Th1 predominance in hypersensitivity pneumonitis

acute HP

18

Th2 predominance in hypersensitivity pneumonitis

subacute/chronic HP

19

eosinophilic lung disease

pulmonary infiltrates with eosinophilia

into airways, alveoli, interstitium

20

simple pulmonary eosinophilia

1-2 weeks
no resp failure
increased blood eosinos
BAL eisonos

21

chronic eosinophilic pneumonia

weeks to months

rare resp failure
increased blood eosinos
eosinos on BAL

22

acute eosinophilic pneumonia

1-5 days
frequent resp railure
no blood eosino elevation

BAL - eosinos, lymphocytes, neutrophils