Flashcards in Immunology Deck (22)
1
host defense in alveolar spaces
alveolar macrophages
Igs, opsonins, surfactants, lymphocyte mediated immunity, neutros and eosinos
2
sarcoidosis
increased lymphocytes
CD4 alveolitis
3
interstitial lung disease in smoker
carbonacesous macrophage
4
scleroderma
systemic sclerosis
neutrophils
eosinophils
5
idiopathic pulmonary fibrosis tx
corticosteroids not indicated
6
nonspecfic interstitial pneumonia tx
favorable response to corticosteroids
7
protective against radiation induced lung fibrosis
ACE
8
increased fibrosis
IGFBP5
9
increased fibroblast activity
endothelin 1
angiotensin II
10
anti-imflammatory and tissue repair promotion
TGF-beta
anti-proliferative
-promote epithelial mesenchymal transition
chronic expression - tissue fibrosis
11
source of TGF beta
alveolar macrophages in idiopathic pulmonary fibrosis
12
genetics of IPF
surfactant protein A2 and C
telomerase
MUC5B
13
systemic sarcoidosis
multisystem granulomatous
noncaseating epitheliod granulomas
depression of DTH response
14
sarcoidosis inflammatory response
TNF-alpha
IL-7
MMP-12
15
hypersensitivity pneumonitis immune response
higher in non-smokers**
lymphocytes, neutrophils, degranulated macrophages
16
hypersensitivity pneumonitis tx
corticosteroids aids recovery initially, long term outcome is unaffected
17
Th1 predominance in hypersensitivity pneumonitis
acute HP
18
Th2 predominance in hypersensitivity pneumonitis
subacute/chronic HP
19
eosinophilic lung disease
pulmonary infiltrates with eosinophilia
into airways, alveoli, interstitium
20
simple pulmonary eosinophilia
1-2 weeks
no resp failure
increased blood eosinos
BAL eisonos
21
chronic eosinophilic pneumonia
weeks to months
rare resp failure
increased blood eosinos
eosinos on BAL
22