Flashcards in Bronchodilators Deck (44)
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1
prednisone
oral corticosteroid
2
montelukast
leukotriene antagonist
3
zafirlukast
leukotriene antagonist
4
anti-IgE Ab
obalizumab
5
bronchospasm
IgE on mast cells
-release histamine and other mediators
blocking single one - not very helpful
corticosteroids - block lots
6
preformed mediators
histamine
TNF alpha
protease
heparin
immediate
vasodilation, edema
7
lipid mediators
minutes
leukotrienes, prostaglandins
mucus secretion
8
cytokines
interleukins, GM-CSF
hours
inflammatory cell proliferation
9
IgE proliferation
IL-4, IL-5
Th2 cell
10
aerosol delivery
lots swallowed
-bets drugs - poor GI absorption
spacer - larger particles deposited before inhales - allows only smaller -which go to small airways
1-5 micrometers - get to small airways
11
DOC for rapid relief of bronchospasm
beta-adrenergic agonist
12
beta agonist overuse
side effect intensify
seek help as soon as decline in efficacy of tx noticed
13
asthma tx
control inflammatory component
bronchodialtor - sympomatic use PRN
14
COPD tx
focus on reversible component
-bronchodilation
15
no hand lung coordination
nebulizer
16
SABA
albuterol
17
LABA
formoterol
salmeterol
18
emergency use
epinephrine - subQ
19
beta agonist MOA
beta2 receptor
stimulate adenylyl cyclase and increase cAMP
relax bronchial smooth m, inhibit mediators of mast cells
20
prevention of nighttime asthma attacks
salmeterol
prophylactic bronchodilation
slow onset - not for acute tx
21
most effective long term treatment persistent asthma
inhaled corticosteroids
recommendations - long acting beta2 agonist in combination with inhaled corticosteroid
22
beta agonist side effect
muscle tremor, cramps, tachyarrythmias, metabolic disturbanceq
23
long term use of LABA
may down-regulate beta-2 receptors
lose protective effect
stop use once asthma control achieved and maintain use of an asthma-controller - inhaled corticosteroid
24
anaphylactic rxn
epinephrine subQ
25
quaternary muscarinic receptor antagonist
ipratropium bromide
inhaled aerosol
poor GI absorption** - swallowed little effect
26
COPD tx
ipratropium
27
long acting muscarinic antagonist
tiotropium
28
theophylline
methylxanthine
-adenosine receptor antagonist
-PDE inhibitor
-hyperpolarize cell membranes
29
intranasal ipratropium
allergic rhinitis
postnasal drip syndrome
30
