Antifungals Flashcards
(44 cards)
MOA of Azoles?
Blocks conversion of lanosterol to ergosterol
Alters cell permeability
Fungistatic
Anti fungal that may elevate ALT in cats?
Terbinafine
Most effective drug for the treatment of systemic mycoses in immunocompromised animals?
Amphotericin B
Anti fungals that cross the BBB?
Flucytosine
Fluconazole
DOC for Blastomycosis and Histoplasmosis?
Itraconazole
Griseofulvin is effective against what fungi?
Dermatophytes
Moa of Allylamine (Terbinafine)?
Inhibits ergosterol synthesis
Inhibits squalene epoxidase
Fungicidal
What anti fungal combination is used to treat systemic mycoses?
Amphotericin B with Azoles
Drug effective against Aspergillus?
Itraconazole
Clotrimazole
Enilconazole
ROA of Fluconazole?
Oral IV
ROA of Amphotericin B?
IV
Which preparation of Amphotericin B is less toxic? Liposomal or Colloidal?
Liposomal
Length of treatment with Ketoconazole?
Long term (3-6 months)
Azoles that require an acidic pH for absorption?
Ketoconazole
Which Azoles inhibit cortisol and/or testosterone synthesis?
Ketoconazole
Treatment of K9 nasal Aspergillosis?
Clotrimazole Enilconazole 5%
ROA of Terbinafine?
Tablet
Topical
Spray (Canada)
Side effects of Ketoconazole?
Inappetance
Pruritis and alopecia in dogs
Inhibits cortisol and testosterone synthesis
Teratogenic - don’t use in pregnant animals
Hepatotoxicity
Effect of Ketoconazole on enzymes?
Inhibitor
ROA of Lufeneron?
PO in dogs
Injection in cats
Moa of Fluctosine?
Inhibits thymidylate synthase
Inhibits nucleic acid synthesis
Fungicidal
Treatment of systemic Aspergillosis?
Itraconazole PO for 2-3 months
Ketoconazole is effective against what local infections?
Dermatophytes
Candida
Malassezia canis
Azole with minimal side effects?
Fluconazole
