GI Drugs

Question 1

Injectable proton pump inhibitor?

Answer 1

Pantoprazole
Lansoprazole

Question 1

Laxatives that attract water into the GI lumen and are not absorbed?

Answer 1

Osmotic cathartics (Magnesium salts, sodium sulfate, sugar alcohols, polyethylene glycols, lactulose)

Question 2

MOA of Misoprostol?

Answer 2

Inhibits cAMP decreasing protein kinase and hydrogen
Icreases mucous and sodium bicarb

Question 2

Treatment of hepatic encephalopathy? MOA?

Answer 2

Lactulose
Ion trapping

Question 3

Treatment of megaesophagus and megacolon?

Answer 3

Cisapride

Question 4

Which H2 blocker inhibits hepatic microsomal enzymes?

Answer 4

Cimetidine

Question 4

Prokinetic serotonin agonists?

Answer 4

Cisapride
Mosapride

Question 4

Use of this class of GI drug can improve the eficacy of pancreatic replacement drug therapy?

Answer 4

H2 blockers

Question 5

Laxatives that absorb water and swell stimulating GI reflex?

Answer 5

Simple bulk laxatives (Metamucil, wheat bran, prunes)

Question 6

Which H2 blocker is much less potent than the others?

Answer 6

Cimetidine

Question 8

Prokinetic H2 bockers?

Answer 8

Nizatidine
Ranitidine

Question 8

Systemic antacid?

Answer 8

Sodium bicarb

Question 8

GI drugs used in liver disease?

Answer 8

Lactulose
Ursodiol

Question 10

Oral proton pump inhibitor?

Answer 10

Omeprazole

Question 11

Anticholinergics are contraindicated in what species?

Answer 11

Horses

Question 12

What makes Ranitidine and Nizatidine prokinetic?

Answer 12

Inhibit AChE to increase ACh

Question 13

MOA of Metoclopramide?

Answer 13

5HT agonist so it stimulates gastric motility

Question 14

Oral antacids?

Answer 14

Magnesium and calcium salts

Question 15

What are the antiulcer drugs that are H2 blockers?

Answer 15

Cimetidine
Ranitidine
Nizatidine
Famotidine

Question 15

MOA of proton pump inhibitors?

Answer 15

Irreversibly inhibit H+/K+ ATPase

Question 15

Treatment of post-op ileus in horse?

Answer 15

Lidocaine

Question 17

Are proton pump inhibitors or H2 blockers more potent?

Answer 17

Proton pump inhibitors

Question 18

Proton pump inhibitor labeled for equine use?

Answer 18

Omeprazole

Question 18

Which pancreatic enzyme replacement therapy drug is most effective?

Answer 18

Viokase

Question 20

MOA of Cisapride and Mosapride?

Answer 20

5HT4 agonist

Question 21

Which opioid has a faster onset, longer duration, better efficacy, and doesnt cross the BBB?

Answer 21

Loperamide

Question 23

What antiulcer drugs are proton pump inhibitors?

Answer 23

Omeprazole Pantoprazole Lansoprazole

Question 24

Pancreatic enzyme replacement therapy drugs?

Answer 24

Viokase Pancreazyme Raw pancreas

Question 25

Laxatives that act as surfactant or stool softeners?

Answer 25

Emollient laxatives (Laxatone, Felilax)

Question 27

What antiulcer drug is a gastro protectant?

Answer 27

Sucralfate

Question 27

What are our prokinetic dopamine antagonists?

Answer 27

Metoclopramide Domperidone

Question 28

Which H2 blockers do not effect GI motility?

Answer 28

Cimetidine Famotidine

Question 29

Bile acid salt that increases bile flow (choleretic)?

Answer 29

Ursodiol

Question 31

MOA of Sucralfate?

Answer 31

Binds to ulcer site in an acidic environment

Question 33

Important side effect of Misoprostal?

Answer 33

Abortifacient

Question 35

Which drug is used to treat NSAID induced gastric ulcers?

Answer 35

Misoprostal

Question 36

Opioids used to treat diarrhea?

Answer 36

Diphenoxylate Loperamide

Question 37

Antimicrobial that stimulates peristalsis?

Answer 37

Erythromycin

Question 38

What antiulcer drug is a prostaglandin analogue?

Answer 38

Misoprostol

Question 40

What receptor does Erythromycin bind to?

Answer 40

Motilin receptor in GI smooth muscle

Question 41

Laxatives that irritate the GI mucosa to stimulate motility and secretion?

Answer 41

Irritant cathartics (Bisacodyl, Phenophthalein)

Question 42

GI protectant that is anti-inflammatory and will turn stool dark?

Answer 42

Bismuth subsalicylate