DNA/RNA Synthesis

Question 1

Treatment of Toxoplasma?

Answer 1

Trimethoprim-Sulfa

Question 1

Adverse effects of Nitrofurans?

Answer 1

GI upset Brown discoloration of the urine

Question 2

What species and what ROA of Enrofloxacin, Orbifloxacin, and Marbofloxacin?

Answer 2

Small animal - oral, IM, otic Pigs and cattle - SC

Question 3

Adverse effects of Sulfonamides and DHFR?

Answer 3

Renal damage Crystal urea Keratoconjunctivitis Sicca (KCS) Hypersensitivity and immune reactions Blood dyscrasia

Question 4

Nitroimidazoles are banned in what animals?

Answer 4

Food producing

Question 4

Nitrofurans are useful for treating what types of infections?

Answer 4

UTIs

Question 5

Common ROA of Sulfonamides and DHFR?

Answer 5

Oral

Question 5

Fluoroquinolone used in beef cattle?

Answer 5

Danofloxacin

Question 6

MOA of Nitrofurans?

Answer 6

Block oxidative decarboxylation

Question 7

Use of Nitrofurantoin?

Answer 7

UTI in small animals

Question 8

Treatment of foot rot?

Answer 8

Sulfamethoxine

Question 8

What infection are Fluoroquinolones not effective in?

Answer 8

Pus

Question 9

MOA of DHFR inhibitors?

Answer 9

Inhibit dihydrofolate reductase

Question 10

Spectrum of Fluoroquinolones?

Answer 10

G- Micoplasma Rickettsia Chlamydia

Question 11

What Fluoroquinolone does not cause blindness in cats?

Answer 11

Pradofloxacin

Question 12

What Fluoroquinolone should not be used in dogs because of bone marrow suppression?

Answer 12

Pradofloxacin

Question 13

Treatment of R. equi?

Answer 13

Rifampin

Question 14

T/F: Nitroimidazoles have immunomodulatory effects?

Answer 14

True

Question 15

Nitrofurans work better in what pH?

Answer 15

Acidic

Question 16

Nitroimidazole used in felines for Tritrichomonas

Answer 16

Ronidazole

Question 16

What percentage of Nitrofurans is excreted unchanged?

Answer 16

50%

Question 16

MOA of Rifampin?

Answer 16

Inhibit the beta subunit of DNA-dependent RNA polymerase

Question 17

Antibiotic that induces microsomal enzymes?

Answer 17

Rifampin

Question 17

Adverse effects of Rifampin?

Answer 17

Teratogenic Orange discoloration of body fluids Hepatitis

Question 19

MOA of Sulfonamides

Answer 19

Compete with PABA for dihydropteroate synthase enzyme

Question 20

Treatment of Mycobacterium?

Answer 20

Rifampin

Question 22

Sulfonamides do not work well in this type of infection.

Answer 22

Pus

Question 23

Do Fluoroquinolones cross the BBB?

Answer 23

No

Question 24

Treatment of Sarcocystis neurons?

Answer 24

Pyrimethamine-Sulfa

Question 24

MOA of Fluoroquinolones?

Answer 24

Inhibit DNA gyrase Inhibit topoisomerase 4 (prevent unwind DNA superhelix)

Question 25

are Nitrofurans static or cidal?

Answer 25

Static

Question 27

Most common Fluoroquinolones?

Answer 27

Enrofloxacin Orbifloxacin Marbofloxacin

Question 29

What is the most common Nitroimidazole?

Answer 29

Metronidazole

Question 31

Spectrum of Sulfonamides and DHFR?

Answer 31

Broad-spectrum G+ G- Chlamydia Some protozoa

Question 32

Which Nitroimidazole is most toxic?

Answer 32

Ronidazole

Question 33

Spectrum of Nitrofurans?

Answer 33

Broad-spectrum except: Pseudomonas Proteus Acinetobacter

Question 35

What species is Trimethoprim-Sulfa used in?

Answer 35

Small animals Equine

Question 36

Nitroimidazole used to treat Trichomoniasis in pigeons?

Answer 36

Carnidazole

Question 38

Do Sulfonamides and DHFR cross the BBB?

Answer 38

Yes

Question 39

MOA of Nitroimidazoles?

Answer 39

Damage DNA and RNA repair enzymes

Question 40

Use of Nitrofurazone/Furazolidine?

Answer 40

Topical in equine (wound dressing)

Question 42

Treatment of Neospora?

Answer 42

Trimethoprim-Sulfa

Question 43

Are Nitroimidazoles bactericidal or bacteriostatic?

Answer 43

Bactericidal

Question 44

Spectrum of Rifampin?

Answer 44

Broad-spectrum specifically: Mycobacterium R. equi

Question 45

What type of bacteria are Nitroimidazoles effective against?

Answer 45

Anaerobic

Question 46

ROA of Fluoroquinolones?

Answer 46

Oral and parenteral

Question 47

Treatment of shipping fever?

Answer 47

Sulfamethoxine

Question 48

Sulfonamide that is not absorbed and treats GI infections?

Answer 48

Sulfasalazine

Question 49

Adverse effects of Fluoroquinolones?

Answer 49

Arthropathy in young and growing animals Blindness in cats

Question 50

What is more specific for protozoa? Trimethoprim-Sulfa or Pyrimethamine-Sulfa?

Answer 50

Pyrimethamine-Sulfa

Question 51

Treatment of coccidia?

Answer 51

Sulfamethoxine

Question 52

ROA for Trimethoprim-Sulfa

Answer 52

Oral or injectable

Question 53

Are Sulfonamides and DHFRs bacteriostatic or bactericidal?

Answer 53

Static alone, Cidal in combo

Question 54

Sulfonamides can affect what blood measurement?

Answer 54

Thyroid

Question 55

Relationship between DHFR inhibitors and Sulfonamides?

Answer 55

Synergistic