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Protein Synthesis Flashcards

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1
Q

Oral availability of erythromycin?

A

Poor, but still used!

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1
Q

Treatment of local MRSA?

A

Mupirocin topically

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2
Q

Why would we use Minocycline?

A

Doxy shortage Better oral bioavailability

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2
Q

Spectrum of Fusidic Acid?

A

G+ MRSA in humans

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2
Q

What subunit does Avilamycin bind to?

A

30s

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3
Q

Spectrum of macrolides?

A

G+

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3
Q

Cross-resistance of Streptogramins?

A

Strep B and Macrolides/Lincosamides

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4
Q

Route of administration of Erythromycin in cattle?

A

IM

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5
Q

Route of administration of most tetracyclines?

A

PO

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6
Q

Macrolides and Lincosamides should not be used in what species?

A

Rabbits Gerbils, Guinea pigs Hamsters

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6
Q

Use of erythromycin?

A

Cattle R. equi in foals

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6
Q

Antibiotic used for gut sterilization?

A

Neomycin

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6
Q

Antibiotic used as a growth promoter outside the US?

A

Avilamycin

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7
Q

Treatment of septic arthritis in foals?

A

Amikacin used intra-articularly (extra-label)

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8
Q

Drugs that are taken up by phagocytes, thereby prolonging the effect?

A

Erytrhyromycin Tulathyromycin Azithromycin

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8
Q

Aminoglycosides are effective against what bacteria?

A

G- aerobes

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9
Q

Which Aminoglycosides can cause auditory injury?

A

Amikacin Neomycin

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9
Q

MOA of Mupirocin?

A

Bind to isoleucyl tRNA synthase

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11
Q

What routes of administration should be avoided with doxy?

A

IV-horses IM/SQ in all species

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12
Q

Species that Azithromycin is used in?

A

Small Animals (specifically for Mycoplasma, Chlamydia, Babesia)

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14
Q

Doxycycline is used in what species?

A

Small Animals

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14
Q

MOA of Amphenicols?

A

Inhibit peptidyl transferase

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15
Q

How do tetracylines work on G- bacteria?

A

Enter the pores

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16
Q

Antibiotic used to treat hepatic encephalopathy?

A

Neomycin But Lactulose is better

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16
What antibiotic is used as a last resort drug in humans for MRSA, VRE, and TB?
Linezolid
16
MOA of Fusidic Acid?
Inhibit attachment of tRNA to the ribosome
17
Subunit that macrolides act on?
50s
18
What parameter should be closely monitored during the use of Aminoglycosides?
Renal function
20
MOA of tetracylines?
Inhibits aminoacyl transfer RNA
22
Spectrum of tetracylines?
Broad
22
Chlortetracyclines are used in what animals?
Food animals
23
MOA of macrolides?
inhibit translocation of ribosome
24
Species that Tilmicosin is used in?
Large Animals
25
What subunit do amphenicols act on?
50s
26
Lincomycin and Clindamycin should not be used in what species?
Horses Ruminants Lagomorphs
27
Spectrum of Lincosamides?
G+
27
MOA of Aminoglycosides?
Prevents attachment of tRNA Alters proofreading
28
Which antibiotic has a post-antibiotic effect?
Aminoglycosides
29
Aminoglycosides exhibit synergism with what other antibiotic?
Penicillins
31
Oxytetracycline's are used in what animals?
Food animals Horses (for Neoricketssia)
33
Antibiotic that inhibits hepatic microsomal enzymes
Chloramphenicol
34
Which antibiotic is more commonly used between Gentamicin and Amikacin?
Amikacin because of lower toxicity
34
Spectrum of Streptogramins?
G+ including MRSA
36
Side effects of amphnicoles
Bone marrow suppression Aplastic anemia
38
Amphenicols antagonize what class of drugs?
Macrolides
40
Uses of chloramphenicol?
Small Animals, especially with MRSA/MRSP
42
Spectrum of amphenicols?
Broad
43
Class of antibiotics that cause yellowing of teeth?
Tetracyclines
44
Lincomycin has cross resistance with what other antibiotics?
Clindamycin (complete) Erythromycin (partial)
45
Tylosin should not be used in what species?
Horses, small herbivores
46
What are our Aminoglycoside drugs?
Gentamicin Tobramycin Amikacin Neomycin Apramycin/Spectinomycin
47
Species that Tulathyromycin is used in?
Beef Non-lactating dairy Swine
48
What are the bactericidal antibiotics?
Aminoglycosides
48
Which Aminoglycosides can cause vestibular injury?
Gentamicin Tobramycin
49
What subunit to Streptogramins bind to?
50s
50
Spectrum of Linezolid?
All G+
52
Class of drugs that "stop pearl stringing"
Amphenicols
54
Distribution of Aminoglycosides?
Remain in ECF
55
Spectrum of Avilamycin?
G+
56
Antibiotic used to treat toxoplasma and anaerobic bacteria in small animals?
Clindamycin
57
Which antibiotics are time dependent?
Tetracyclines Amphenicols Macrolides Lincosamides
58
What subunit does Aminoglycosides bind to?
30s
59
What subunit does tetracylines act on?
30s
60
MOA of Linezolid?
Prevents iniation
60
Route of administration of Fusidic Acid?
Topical Hepatotoxicity with parenteral use
62
Tylosin is used in what species?
Cattle Swine SA (for diarrhea)
63
Side effect of Erythromycin?
Vomiting
64
Antibiotic that is fatal to humans with a needle stick?
Tilmicosin
65
Antibiotic used to treat avian medicineoxa?
Apramycin/Spectinomycin
67
Drug used to treat mastitis in dairy cattle via intramammary infusion?
Pirlimycin
68
Which antibiotic is concentration dependent?
Aminoglycosides
70
Route of admin for florfenicol?
IM SQ
72
Route of administration of Gentamicin in small animal?
Parenteral
74
Route of administration of chlortetracycline's?
Water or feed additive
75
Route of administration of Gentamicin in horses?
Intrauterine IV extra-label
76
Macrolides should not be given orally to what species?
Ruminants Adult horses
77
Side effects of Aminoglycosides?
Nephrotoxic Ototoxic Vestibular and auditory injury
78
Florfenicol is used in what species?
Large Animals
79
Tetracyclines are antagonistic to what class of antibiotics?
Penicilins
80
Antibiotic used for resistant G- infection in small animals?
Amikacin
81
Side effect of Tilmicosin
Cardiotoxicity- avoid IV

Pharmacology 2 (13 decks)

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