Cell Wall Synthesis

Question 1

Beta lactam antibiotics are generally most effective against what bacteria?

Answer 1

G+

Question 1

First generation Cephalosporins have a similar spectrum to what antibiotic?

Answer 1

Ampicillin

Question 1

What is considered the first-line Cephalosporin?

Answer 1

Cephalexin/Cefadroxil

Question 1

How does the toxic potential of Carbapenems compare to other drugs?

Answer 1

Greater toxic potential

Question 3

Third gen Cephalosporin used for respiratory disease, foot rot, and mastitis?

Answer 3

Ceftiofur

Question 4

ROA of Bacitracin?

Answer 4

PO in poultry
Topical

Question 5

What is Cloxacillin used to treat?

Answer 5

Mastitis in cattle

Question 5

Vancomycin is great against treating what GI bacteria and why?

Answer 5

C. difficile because it is not absorbed orally and remains in the GIT

Question 6

What is the anti-pseudomonas penicillin?

Answer 6

Ticarcillin

Question 6

Spectrum of Carbapenems and Monobactams?

Answer 6

G+
G-
Pseudomonas
Not good against resistant Staph or enterococci

Question 6

Polymyxin B combined with Neomycin can cause fatal anaphylaxis in what species?

Answer 6

Cats

Question 7

Beta lactams that cross the BBB?

Answer 7

Carbapenems/Monobactams

Question 8

Penicillin G is most commonly used in what animals?

Answer 8

Large animals

Question 9

Why are Beta lactam antibiotics generally low in toxicity?

Answer 9

Mammalian cells do not have a cell wall

Question 10

MOA of Beta lactam antibiotics?

Answer 10

Prevent cross-linkage of peptidoglycan layers leading to cytolysis

Question 11

Which is more broad-spectrum? Cephalosporins or Penicillins?

Answer 11

Cephalosporins

Question 12

What are the first generation Cephalosporins?

Answer 12

Cephalexin/Cefadroxil
Cefazolin
Cephapirin

Question 13

What are third generation Cephalosporins effective against?

Answer 13

G- and anaerobes
Less G+ activity

Question 13

ROA of Cefoxitin?

Answer 13

IV for serious infections

Question 13

Vancomycin cannot be used in what animals?

Answer 13

Food animals

Question 14

Bacitracin requires what compound to be active?

Answer 14

Zinc

Question 14

Antibiotic that affects cell membrane rather than inhibiting it?

Answer 14

Polymyxin B

Question 17

Time dependent cell wall inhibitors?

Answer 17

Penicillin
Cephalosporin
Carbapenems/Monobactams
Vancomycin

Question 18

MOA of Polymyxin B?

Answer 18

Binds to LPS
Cationic detergent

Question 19

ROA of first gen Cephalosporins?

Answer 19

Cephalexin PO Cefazolin parenteral Cephapirin intramammary

Question 21

Post anitbiotic effect?

Answer 21

Penicillin (some) Carbapenems/Monobactams

Question 23

How is Amoxicillin usually administered?

Answer 23

Oral

Question 24

Ceftiofur is used in what species?

Answer 24

Large animals

Question 25

Third gen Cephalosporin used in small animal for G- infections?

Answer 25

Cefpodoxime

Question 27

Spectrum of Penicillin?

Answer 27

G+ Anaerobes Spirochetes

Question 27

ROA of Carbapenems/Monobactams?

Answer 27

Parenteral

Question 28

MOA of Vancomycin?

Answer 28

Prevent the assembly of amino acids

Question 30

When should Amoxicillin-Clavulanic Acid be used?

Answer 30

When bacteria is producing Beta-lactamase

Question 31

How do bacteria respond to Betalactam antibiotics?

Answer 31

Produce beta lactamases which break down the betalactam ring

Question 31

Polymyxin B is not technically an antibiotic but is classified as what?

Answer 31

Antiseptic

Question 32

How do second generation Cephalosporins differ from first generation?

Answer 32

Greater efficacy against G-

Question 32

Side effects of Vancomycin?

Answer 32

Histamine release Nephrotox Ototox

Question 33

How is Ampicillin usually administered?

Answer 33

Parenteral

Question 35

Cefovecin is used in what species?

Answer 35

Small animals (Convenia®)

Question 36

Spectrum of Bacitracin?

Answer 36

G+

Question 37

What are the third gen Cephalosporins?

Answer 37

Ceftiofur Cefovecin Cefpodoxime

Question 38

Treatment of Staph and Strep pyoderma in dogs and Pasteurella in cats?

Answer 38

Cefovecin

Question 40

Cephalosporin used for mastitis in cattle?

Answer 40

Cephapirin Ceftiofur

Question 41

Spectrum of Polymyxin B?

Answer 41

G-

Question 42

What is the second gen Cephalosporin?

Answer 42

Cefoxitin

Question 42

ROA of Polymyxin B?

Answer 42

Topical

Question 44

What are our Beta lactam antibiotics?

Answer 44

Penicillin Cephalosporins Carbapenems Monobactams

Question 45

Penicillin and Cephalosporin are contraindicated in what species?

Answer 45

Reptiles Birds Guinea pigs (PO) Chinchillas (PO) Horses (PO) Ruminants (PO)

Question 47

Bactericidal cell wall inhibitors?

Answer 47

Penicillins Cephalosporins Carbapenems/Monobactams Vancomycin

Question 49

DD-transpeptidase is also known as?

Answer 49

Penicillin binding protein

Question 50

Which Cephalosporin is administered as a prodrug?

Answer 50

Cefpodoxime

Question 52

What are the Carbapenems?

Answer 52

Imipenem Meropenem

Question 53

Prophylactic Cephalosporin?

Answer 53

Cefazolin

Question 54

Ampicillin/Amoxicillin are commonly used in what species?

Answer 54

Small animal Equine Cattle for mastitis

Question 55

MOA of Bacitracin?

Answer 55

Blocks isoprenyl pyrophosphate enzyme

Question 56

Spectrum of Vancomycin?

Answer 56

G+ MRSA (last resort) Beta-lactam resistance enterococci

Question 57

How is Penicillin G usually administered?

Answer 57

Parenteral