Chemotherapy

Question 1

Chemotherapy drug that is administered as a prodrug?

Answer 1

Cyclophosphamide

Question 2

Most common side effect of Doxorubicin?

Answer 2

Myelosuppression
GI
Dose-dependent cardiomyopathy in Dobermans, Rottweilers, giant breeds, and ABCB1 mutants
Nephropathy in cats

Question 3

MOA of Doxorubicin?

Answer 3

Inhibits topoisomerase 2
Inhibits DNA helicase

Question 3

Treatment of lymphoreticular neoplasms?

Answer 3

Vincristine
Cytosine Arabinoside
Prednisone

Question 3

Administration of Vincristine with L-Asparaginase increases the risk of this side effect?

Answer 3

Myelosuppression

Question 4

Why can Bisphosphonate and Alendronate treat cancer?

Answer 4

Osteoclast inhibitors

Question 5

Doxorubicin is used in the treatment of what 3 cancers?

Answer 5

Lymphoma
Carcinoma
Osteosarcoma

Question 6

Side effects of Lomustine and Carmustine?

Answer 6

Myelosuppression
Thrombocytopenia (reversible)
Chronic hepatotoxicity (irreversible)

Question 7

Route of administration of Cyclophosphamide?

Answer 7

IV
PO

Question 7

Treatment of lymphoreticular neoplasms, carcinomas, sarcomas, and TVT?

Answer 7

Vincristine and Vinblastine

Question 8

Most common side effect of Cytosine Arabinoside?

Answer 8

Myelosuppression

Question 9

Drug similar to Cisplatin used in cats?

Answer 9

Carboplatin

Question 10

Route of administration of Methotrexate?

Answer 10

Parenteral
Oral

Question 10

Major side effect of L-Asparaginase?

Answer 10

Anaphylaxis - give IM/SC to reduce the risk of this
Pancreatitis

Question 12

Route of administration of Carmustine?

Answer 12

IV

Question 13

Which vesicant do you treat extravasation using heat?

Answer 13

Vincristine and Vinblastine

Question 14

MOA of Platinum compounds?

Answer 14

Bind to DNA residues causing cross-linking preventing replication

Question 14

What is the most commonly used cytotoxic antibiotic?

Answer 14

Doxorubricin

Question 14

Route of administration of Alendronate?

Answer 14

Oral

Question 16

Route of administration of Cisplatin?

Answer 16

IV
Implant for dogs

Question 17

Most common side effect of Methotrexate?

Answer 17

GI

Question 18

Most common side effect of Cyclophosphamide?

Answer 18

Myelosuppression

Question 18

MOA of Vincristine and Vinblastine?

Answer 18

Bind to beta tubulin and inhibit microtubule formation which prevents cell division during metaphase of mitosis

Question 19

Methotrexate is a competitive inhibitor of what enzyme?

Answer 19

Dihydrofolate reductase
It is similar to trimethoprim or pyrimethamine

Question 20

Cancer vaccine in dogs?

Answer 20

Oral melanoma

Question 21

Treatment of Chronic Lymphocytic Leukemia?

Answer 21

Chlorambucil

Question 22

Cell cycle specific chemo drugs?

Answer 22

Vincristine and Vinblastine during G2 and M phase Methotrexate and Cytosine Arabinoside during S phase L-Asparaginase (Elspar®) during G1

Question 24

What biochemistry value should be monitored when using Lomustine and Carmustine?

Answer 24

ALT

Question 26

Route of administration of Melphalan?

Answer 26

Oral

Question 27

Route of administration of Lomustine?

Answer 27

Oral

Question 28

Treatment of Grade 2 and 3 canine mast cell tumors?

Answer 28

Toceranib

Question 29

Treatment of granulomatous meningoencephalitis (GME)?

Answer 29

Cytosine Arabinoside

Question 30

Route of administration of Toceranib?

Answer 30

Oral

Question 31

Bisphosphonate and Alendronate are useful in what types of cancer?

Answer 31

Bone neoplasias Hypercalcemia of malignancy

Question 32

Why can NSAIDs be used to help treat cancer?

Answer 32

Inhibit COX-2 in carcinomas and transitional cell carcinomas

Question 33

L-Asparaginase is used to treat?

Answer 33

Lymphoma

Question 35

In order to prevent nephrotoxicity, Cisplatin should be preceded and followed by infusion of what?

Answer 35

Saline solution

Question 36

Treatment of Multiple Myeloma?

Answer 36

Melphalan

Question 36

MOA of Methotrexate and Cytosine Arabinoside?

Answer 36

Impair DNa synthesis during S phase

Question 37

Does Methotrexate or Cytosine Arabinoside distribute to the CNS?

Answer 37

Cytosine Arabinoside

Question 38

Cytosine Arabinoside is an analog of what structure?

Answer 38

Pyrimidine

Question 39

Alkylating agent that can be used to treat CNS neoplasms?

Answer 39

Lomustine and Carmustine

Question 40

MOA of L-Asparaginase (Elspar®)?

Answer 40

Inhibition of protein synthesis

Question 41

Side effects of Cisplatin?

Answer 41

Myelosuppression Nephrotoxicity Ototoxicity (rare) Neurotoxicity (rare)

Question 42

Most common side effect of Melphalan?

Answer 42

Myelosuppression

Question 43

Administration of this drug along side chemo increases efficacy against transitional cell carcinoma?

Answer 43

Piroxicam

Question 45

Cisplatin should not be used in what species and why?

Answer 45

Cats because of fatal pulmonary toxicosis

Question 46

Route of administration of Bisphosphonate?

Answer 46

IV

Question 47

Side effects of Chlorambucil?

Answer 47

Not common Myelosuppression occasionally

Question 48

Rout of administration of Chlorambucil?

Answer 48

Oral

Question 50

Route of administration of Cytosine Arabinoside?

Answer 50

SC IV (CRI)

Question 52

Chemotherapy drug causing sterile hemorrhagic cystitis?

Answer 52

Cyclophosphamide

Question 53

Side effects of Toceranib?

Answer 53

GI Myelosuppression

Question 54

Elimination of Melphalan?

Answer 54

Plasma hydrolysis

Question 55

MOA of Toceranib?

Answer 55

Tyrosine kinase inhibitor

Question 56

Drug to be given prior to L-Asparaginase to reduce allergic reactions?

Answer 56

Diphenhydramine (Benadryl®)