Autacoids

Question 1

What are our ACE inhibitors?

Answer 1

Captopril
Enalapril
Lisinopril
Benazepril

Question 1

Phospholipase A2 inhibitor

Answer 1

Corticosteroids

Question 1

Oclacitinib does not inhibit which JAK?

Answer 1

JAK2 (hematopoietic)

Question 3

Inhibition of renin secretion?

Answer 3

Angiotensin 2
ADH
Hypertension
Increased reabsorption of sodium
Beta 1 adrenergic blockers

Question 4

Autacoids that increase uveoscleral outflow by stimulating FP receptors in the eye?

Answer 4

Latanoprost
Travoprost
Bimatoprost

Question 4

COX inhibitors?

Answer 4

NSAIDs

Question 5

Clinical use of Fluoxetine?

Answer 5

Antidepressant

Question 5

MOA of Zafirlukast?

Answer 5

Leukotriene receptor antagonist

Question 6

Clinical use of Miropitant citrate (Cerenia®)?

Answer 6

Prevents and treats acute vomiting in dogs

Question 6

MOA of Misoprostol?

Answer 6

Decreases acid secretion

Question 8

Where do autacoids have effect?

Answer 8

Smooth muscle

Question 8

Clinical use of Zafirlukast?

Answer 8

Prevents bronchoconstriction in asthmatic cats

Question 9

What two classes of drugs are angiotensin 2 antagonists?

Answer 9

ACE inhibitors
Angiotensin 2 receptor antagonists

Question 9

Reproductive drugs that cause luteolysis and stimulate motility?

Answer 9

Dinoprost trimethamine
Cloprostenol
Fenprostalene
Fluprostenol

Question 10

MOA of Cisapride?

Answer 10

5-HT4 receptor agonist in enteric neurons

Question 10

Stimulation of renin secretion?

Answer 10

Hypotension
Decreased renal blood flow
Low sodium or chloride in blood
Sympathetic stimulation (Beta 1 adrenergic)

Question 11

Clinical use of Mirtazapine?

Answer 11

Antidepressant
Antiemetic

Question 12

Angiotensin 2 stimulates the secretion of what?

Answer 12

Aldosterone

Question 14

MOA of Maropitant citrate (Cerenia®)?

Answer 14

Blocks NK1 receptors thereby preventing Substance P binding

Question 16

MOA of Ondansetron?

Answer 16

5HT3 antagonist

Question 18

MOA of Cyproheptadine?

Answer 18

H1 blocker
Serotonin antagonist

Question 20

Clinical use of Ondansetron?

Answer 20

Prevent nausea and vomiting

Question 22

MOA of Fluoxetine?

Answer 22

Selective serotonin reuptake inhibitor

Question 22

Clinical use of Latanoprost, Travoprost, and Bimatoprost?

Answer 22

Open-angle glaucoma
Ocular hypertension

Question 23

MOA of Zileuton?

Answer 23

5-Lipoxygenase inhibitor

Question 25

What is our angiotensin 2 receptor antagonist?

Answer 25

Losartan Blockey type 1 receptors

Question 26

Effect of Metoclopramide centrally and peripherally?

Answer 26

``` Centrally = antiemetic Peripherally = prokinetic ```

Question 27

MOA of Metoclopramide?

Answer 27

5HT3 antagonist D1 and D2 antagonist

Question 28

Clinical use of Cyproheptadine?

Answer 28

Antihistamine Appetite stimulant Treatment of Serotonin syndrome

Question 30

Biological factors that act as local hormones, transmitters, and modulators

Answer 30

Autacoids

Question 31

What is the function of Renin?

Answer 31

Converts angiotensinogen to angiotensin 1

Question 32

JAK inhibitor?

Answer 32

Oclacitinib (Apoquel®)

Question 33

MOA of Mirtazapine?

Answer 33

Alpha 2 adrenergic antagonist 5HT2 and 5HT3 antagonist

Question 34

Clinical use of Misoprostol?

Answer 34

Antiulcer

Question 35

Clinical use of Zileuton?

Answer 35

Prevents asthmatic bronchoconstriction

Question 36

Serotonin is also known as?

Answer 36

5-HT