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Flashcards in Antifungals Deck (24)
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1

Blocks lanosterol synthesis through inhibiting squalene epoxidase

Terbinafine

2

Cell wall synthesis inhibitor by inhibiting B glucan

Echinocandins (fungins)

3

Forms membrane pores by binding to ergosterol

Polyenes - amphotericin b, nystatin

4

Inhibits DNA and RNA biosynthesis by conversion to 5FU by storing deaminase

5 flucytosine

5

Interferes with microtubule function

Griseofulvin

6

For serious systemic Mycoses
Fever and chills (shake and bake), Nephrotoxicity, anemia, IV phlebitis

Amphotericin B

7

Topical polyene
Swish and swallow for thrush
Candidiasis

Nystatin

8

Cryptococcal meningitis for AIDS patients
Candida infections

Fluconazole

9

Blastomyces, coccidioides, histoplasma

Itraconazole

10

Topical fungal infections

Clotrimazole
Miconazole

11

Azoles toxicity

Testosterone synthesis inhibitor, liver dysfunction

12

Systemic fungal infections (used with amphotericin B)

Flucytosine

13

Flucytosine Toxicity

Bone marrow suppression

14

Invasive aspergillosis, candida

Echinocandins

15

Echinocandins toxicity

Flushing

16

Dermatophytoses

Terbinafine

17

Terminating toxicity

Hepatotoxicity taste disturbance

18

Superficial infections

Griseofulvin

19

Griseofulvin toxicity

Teratogenic, carcinogenic, increased p450 and warfarin metabolism

20

Toxoplasmosis

Pyrimethamine

21

Trypanosoma brucei

Suramin and melarsoprol

22

Trypanosoma cruzi

Nifurtimox

23

Leishmaniasis

Sodium stibogluconate

24

Inhibits cytochrome p450 that converts lanosterol to ergosterol

Azoles