Flashcards in Antifungals Deck (24)
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1
Blocks lanosterol synthesis through inhibiting squalene epoxidase
Terbinafine
2
Cell wall synthesis inhibitor by inhibiting B glucan
Echinocandins (fungins)
3
Forms membrane pores by binding to ergosterol
Polyenes - amphotericin b, nystatin
4
Inhibits DNA and RNA biosynthesis by conversion to 5FU by storing deaminase
5 flucytosine
5
Interferes with microtubule function
Griseofulvin
6
For serious systemic Mycoses
Fever and chills (shake and bake), Nephrotoxicity, anemia, IV phlebitis
Amphotericin B
7
Topical polyene
Swish and swallow for thrush
Candidiasis
Nystatin
8
Cryptococcal meningitis for AIDS patients
Candida infections
Fluconazole
9
Blastomyces, coccidioides, histoplasma
Itraconazole
10
Topical fungal infections
Clotrimazole
Miconazole
11
Azoles toxicity
Testosterone synthesis inhibitor, liver dysfunction
12
Systemic fungal infections (used with amphotericin B)
Flucytosine
13
Flucytosine Toxicity
Bone marrow suppression
14
Invasive aspergillosis, candida
Echinocandins
15
Echinocandins toxicity
Flushing
16
Dermatophytoses
Terbinafine
17
Terminating toxicity
Hepatotoxicity taste disturbance
18
Superficial infections
Griseofulvin
19
Griseofulvin toxicity
Teratogenic, carcinogenic, increased p450 and warfarin metabolism
20
Toxoplasmosis
Pyrimethamine
21
Trypanosoma brucei
Suramin and melarsoprol
22
Trypanosoma cruzi
Nifurtimox
23
Leishmaniasis
Sodium stibogluconate
24
