Antifungals

Question 1

Blocks lanosterol synthesis through inhibiting squalene epoxidase

Answer 1

Terbinafine

Question 2

Cell wall synthesis inhibitor by inhibiting B glucan

Answer 2

Echinocandins (fungins)

Question 3

Forms membrane pores by binding to ergosterol

Answer 3

Polyenes - amphotericin b, nystatin

Question 4

Inhibits DNA and RNA biosynthesis by conversion to 5FU by storing deaminase

Answer 4

5 flucytosine

Question 5

Interferes with microtubule function

Answer 5

Griseofulvin

Question 6

For serious systemic Mycoses

Fever and chills (shake and bake), Nephrotoxicity, anemia, IV phlebitis

Answer 6

Amphotericin B

Question 7

Topical polyene
Swish and swallow for thrush
Candidiasis

Answer 7

Nystatin

Question 8

Cryptococcal meningitis for AIDS patients

Candida infections

Answer 8

Fluconazole

Question 9

Blastomyces, coccidioides, histoplasma

Answer 9

Itraconazole

Question 10

Topical fungal infections

Answer 10

Clotrimazole

Miconazole

Question 11

Azoles toxicity

Answer 11

Testosterone synthesis inhibitor, liver dysfunction

Question 12

Systemic fungal infections (used with amphotericin B)

Answer 12

Flucytosine

Question 13

Flucytosine Toxicity

Answer 13

Bone marrow suppression

Question 14

Invasive aspergillosis, candida

Answer 14

Echinocandins

Question 15

Echinocandins toxicity

Answer 15

Flushing

Question 16

Dermatophytoses

Answer 16

Terbinafine

Question 17

Terminating toxicity

Answer 17

Hepatotoxicity taste disturbance

Question 18

Superficial infections

Answer 18

Griseofulvin

Question 19

Griseofulvin toxicity

Answer 19

Teratogenic, carcinogenic, increased p450 and warfarin metabolism

Question 20

Toxoplasmosis

Answer 20

Pyrimethamine

Question 21

Trypanosoma brucei

Answer 21

Suramin and melarsoprol

Question 22

Trypanosoma cruzi

Answer 22

Nifurtimox

Question 23

Leishmaniasis

Answer 23

Sodium stibogluconate

Question 24

Inhibits cytochrome p450 that converts lanosterol to ergosterol

Answer 24

Azoles