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Flashcards in Parkinsons and Psychiatric Drugs Deck (64)
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1

What is the drug of choice for parkinsonism?

LEVODOPA - CARBIDOPA
MOA: Levodopa is a dopamine precursor and carbidoba inhibits peripheral metabolism of DOPA decarboxylase

2

What is the phenomenon which manifests as alternating periods of improved mobility and akinesia, occurring over a few hours to days during treatment?

On-Off Phenomenon

3

What is the partial agonist at dopamine D3 receptors used in treatment of parkinsons disease during off periods?

Apomorphine

4

What is the phenomenon which manifests as deterioration of drug effect in between medication doses due to progressive destruction of nigostriatal neurons?

Wearing off phenomenon

5

What is the drug that blocks L-dopa metabolism by inhibiting COMT in periphery which is used as the drug of choice for wearing off phenomenon?

Entacapone

6

What is the difference between Entacapone and Tolcapone

Entacapone acts only on the periphery while Tolcapone acts both on the CNS and periphery

7

What are the side effects of Levodopa-carbidopa?

Emesis, Dyskinesia (Choreoathetosis), Behavioral changes, on off phenomenon, wearing off phenomenon, postural hypotension

8

What is the side effect of Apomorphine?

Severe nausea

9

What is the drug given as premedication to avoid severe nausea when giving Apomorphine?

Trimethobenzamide (an anti-emetic)

10

What is a partial agonist of D2 receptors used in the treatment of parkinsons? What are the side effects of giving this drug?

Bromocriptine
Side effects: Erythromelalgia (due to intermittent blockage of vessels) and pulmonary fibrosis

11

What drugs is classified as a MAO Type B inhibitors which are used in the treatment of parkinsons?

Selegiline and Rasagiline

12

What is an anti-parkinsonism drug which antagonizes the effects of adenosine at adenosine A2 receptors which is also used in the treatment of influenza? Side effect?

Amantadine
Side Effect: Livedo reticularis and peripheral edema

13

What drugs can cause livedo reticularis

Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

14

What is a partial agonist of Dopamine D3 receptors used in the treatment of Parkinsons and Restless leg syndrome? What are its side effects?

Pramipexole
SE: compulsive gambling, hypersexuality, overeating, uncontrollable tendency to fall asleep

15

What is a typical antipsychotic which blocks D2 receptors>> 5HT2 receptors which causes failure of ejaculation, postural hypertension, marked sedation, CORNEAL AND LENS DEPOSITS?

Chlorpromazine
Class: phenothiazine

16

What is the only antipsychotic which has fatal overdose and has the strongest autonomic effects?

Thioridazine
Class: Phenothiazine
Similar Drugs: Fluphenazine, Perphenazine, Prochlorperazine, Trifluoroperazine

17

What antipsychotic drug that can be used as an anti-emetic?

Prochlorperazine

18

Which among the typical antipscyhotics which has the weakest autonomic effects and is least sedating?

Haloperidol
Droperidol
Class: Butyrophenone

19

Which among the typical antipschotics which is used in the treatment of Huntington's disease and Tourette's syndrome?

Haloperidol
Droperidol

20

What is the difference between atypical and typical antipsychotics?

Typical antipsychotics blocks D2 receptors >> 5HT2 receptors
Atypical antipsychotics blocks 5HT2 receptors
>> D2 receptors

21

What are examples of atypical antipsychotic drugs?

Clozapine, olanzapine Quetiapine, Risperidone, Ziprasidone, Aripiprazole

22

What is the only anti-psychotic drug that reduces the risk of suicide?

Clozapine

23

What atypical antipsychotic drug that causes weight gain, hyperglycemia, hyperlipidemia, myocarditis, agranulocytosis, seizures, ileus and hypersalivation (sialorrhea)?

Clozapine

24

Drugs that causes agranulocytosis

Clozapine
Colchicine
Co-trimoxazole
Aminopyrine
Phenylbutazone
PTU
Indomethacin
Tocainide

25

What is the antipsychotic drug that causes hypnagogic hallucinations, sleep paralysis, cataracts and priapism?

Quetiapine

26

Aside from clozapine, give an antipsychotic drug that also causes weight gain, hypoglycemia and hyperlipidemia

Olanzapine

27

What is the only antipsychotic drug that is approved for schizophrenia in the youth?

Risperidone

28

What is the anti-psychotic drug that can cause postural hypertension and torsade de pointes?

Ziprasidone

29

What is the anti-psychotic drug that has no atropine-like effects, little or no tendency to cause hyperglycemia, hyperprolactinemia or weight gain and causes increased mortality in elderly patients with dementia-related psychosis

Ziprasidone

30

Which among the antipsychotic drugs is least sedating? It has also no atropine-like effects, little or no tendency to cause hyperglycemia, hyperprolactinemia and weight gain?

Aripiprazole