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Flashcards in Cardiovascular drugs Deck (93)
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1

Examples of Thiazide diuretics

Hydrochlorothiazide
Chlorthalidone
Chlorthiazide
Indapamide
Metolazone

2

MOA of Thiazide Diuretics

Inhibit Na/Cl transporter in the DCT and reduced excretion of calcium

3

Side effects of thiazide diuretics

Hypokalemic metabolic alkalosis; Sulfa allergy
Hyperglycemia
Hyperlipidemia
Hyperuricemia
Hypercalcemia
(HYPER-GLUC)

4

Examples of Loop Diuretics

Furosemide, Bumetanide, Torsemide, Ethracrynic acid

5

MOA of Loop Diuretics

Inhibit Na/K/2Cl transporter in the Thick ascending loop of Henle and increased Ca excretion

6

Loop diuretic which does not trigger sulfa allergy

Ethracrynic Acid

7

Drugs that irreversibly blocks the vesicular monoamine transporter (VMAT)

Nerve terminal blocker:
GUANETHIDINE
RESERPINE

8

Side effect of reserpine

Suicidal ideation

9

A vasodilator that alters intracellular calcium metabolism thus causing relaxation of the arteriolar smooth muscle, decreases afterload

Hydralazine

10

Drugs that induces Lupus

Hydralazine, Isoniazid, Procainamide, Penicillamine

11

What is the use of hydralazine in heart failure

when combined with ISDN, more effective in treating acute heart failure in Blacks

12

Side effect of hydralazine

reflex tachycardia

13

A hypertensive drug that is used in the treatment of alopecia

Minoxidil
MOA for hypertension: opening of K+ Channels --> hyperpolarization --> vasodilation

14

Examples of Non-dihydropyridine calcium channel blocker (inhibits voltage-gated L type receptors)

verapamil, diltiazem
(Cardiac>vascular)

15

Side effects of non-dihydropyridine receptors blockers

Constipation, Pretibial edema, gingival hyperplasia

16

Besides its antihypertensive property, what are the other Uses of nondihydropyridine receptors Ca channel blockers

Angina, SVT

17

Examples of dihydropyridine receptors Ca channel blockers

Amlodipine, felodipine, Nicardipine, Nisoldipine, Isradipine
Vascular>Cardiac

18

Side effect of dihydropyridine ca channel blockers

Pretibial edema, flushing, constipation

19

A parenteral vasodilator that relaxes venous and arteriolar smooth muscle (decreasing both preload and afterload)

Nitroprusside

20

Side effect of Nitroprusside

Cyanide Toxicity
Tx: Inhaled Amyl Nitrite, IV sodium nitrite, IV sodium thiosulfate

21

What is the side effect for the treatment of the side effect of nitroprusside

Methemglobinemia
Tx: oxygen supplement and methylene blueA

22

A dopamine agonist which is a parenteral vasodilator

Fenoldopam
Used in hypertensive emergencies
May cause hypokalemia

23

Anti-hypertensive which is a Renin antagonist

Aliskiren

24

Treatment for malignant hypertension

Nitroprusside, fenoldopam, diazoxide (vasodilators) plus diuretics (furosemide) and beta-blockers

25

Ultrashort acting nitrite used in the treatment of cyanide poisoning (MOA: releases NO, increases cGMP and relaxes smooth muscle)

Amyl nitrite

26

Short-acting nitrite used in the treatment of angina and acute coronary syndromes

Isosorbide dinitrate
Isosorbide mononitrate (maintenance)

27

Side effects of nitrites

Headache
Tolerance (transdermal)
dangerous hypotension when combined with phosphodiesterase (PDE) inhibitors (e.g. sildenafil, vardenafil and tadalafil)

28

DOC for Prinzmetal's angina

Diltiazem

29

Anti-angina drug that can be used in the treatment of raynaud's phenomenon

Diltiazem

30

drugs that can cause gingival hyperplasia

Nifedipine, Cyclosporin, Phenytoin, Verapamil
(NapaCa Pangit ng gingiVa mo)