Flashcards in Endocrine Drugs Deck (82)
What drug is used in management of short stature that acts by increasing release of IGF-1 in the liver and cartilage, stimulating skeletal muscle growth, amino acid transport, protein synthesis and cell proliferation?
What drug is used as performance-enhancing drug that is banned by athletic committees?
What is the somatostatin analog used in treatment for acromegaly, pituitary adenoma, carcinoid, gastrinoma, glucagonoma, variceal bleeding?
Drug used to activate FSH receptors for controlled ovarian hyperstimulation and for management of infertility due to hypogonadism in men
GnRH analog which increases LH and FSH with intermittent administration and reduces LH and FSH with prolonged continuous administration.
Used for the treatment of endometriosis, myoma uteri, precocious puberty and prostate cancer
GnRH antagonist used in prostate cancer and prevention of premature LH surge
Note: does not cause a tumor flare up when used for treatment of advanced prostate cancer
Dopamine agonist but a partial agonist at dopamine D2 receptors in the brain to inhibit prolactin release
What is the side effect of bromocriptine other than erythromelalgia and pulmonary fibrosis?
What is the drug of choice for treatment of pregnant hyperthyroid patients which has a slow onset of action (3-4 weeks to take full effect)
Drug class: Thioamide
What is the mechanism of action of propylthiouracil?
It inhibits thyroid peroxidase reactions
It inhibits iodine organification and peripheral conversion of T4 and T3
What is the treatment of choice for Myxedema coma (progressive weakness, stupor, hypothermia, hypoventilation, hypoglycemia, hyponatremia, water intoxication, shock and death due to severe hypoglycemia)
IV loading dose of Levothyroxine 300-400 mcg
What are the side effects of Propylthiouracil?
Agranulocytosis, Urticaria, Fulminant Hepatitis, Lupus-like syndrome, vasculitis, Hypoprothrombinemia, Exfoliative dermatitis, Polyserositis, Arthralgia
Prenatal exposure to Methimazole results to?
Aplasia cutis congenita
What is the treatment that reduces the size and vascularity of thyroid gland. MOA includes inhibiting iodine organification and hormone release?
What do you call the phenomenon in which the ingestion of iodine causes hypothyroidism?
What do you call the phenomenon in which the ingestion of iodine causes hyperthyroidism?
What is the drug that cause clinical improvement without altering thyroid hormone levels. It inhibits peripheral conversion of T4 and T3
What are the three drugs that inhibits peripheral conversion of T4 to T3
What is the drug of choice for thyroid storm?
Propylthiouracil then Iodides to retard release of thyroid hormones
Give three drugs that induces hyperthyroidism?
What drug induces hypo and hyperthyroidism?
- Has the ability to block the peripheral conversion of T4 to T3 (Tx: Levothyroxine)
- Iodine induced mechanism in persons with an underlying disease or through an inflammatory mechanism that causes leakage of thyroid hormone
(tx: Thioamides or corticosteroids)
What glucocorticoid synthesis inhibitor that inhibits desmolase and reduced synthesis of all hormonally active steroids used in the treatment of breast cancer and cushing syndrome?
Note: Used by body builders to lower circulating levels of cortisol in the body and prevent muscle loss
Which among the azole antifungals inhibits cholesterol side-chain cleavage, cytochrome P450 and other enzymes necessary for synthesis of all steroids? Used in the treatment of adrenal carcinoma, hirsutism, breast cancer, prostate cancer, cushing's syndrome and fungal infections
What glucocorticoid synthesis inhibitor that selectively inhibits steroid 11-hydroxylation used in the diagnostic testing for Cushing's syndrome? This is also the drug of choice for pregnant patients with cushing's syndrome
Examples of progestins
What are the side effects of progestins?
Decreased HDL and Weight gain
What progestin is used as an appetite stimulant
What is the drug used as an emergency contraception