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Flashcards in Endocrine Drugs Deck (82)
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1

What drug is used in management of short stature that acts by increasing release of IGF-1 in the liver and cartilage, stimulating skeletal muscle growth, amino acid transport, protein synthesis and cell proliferation?

Somatropin
(Growth hormone)

2

What drug is used as performance-enhancing drug that is banned by athletic committees?

Somatropin

3

What is the somatostatin analog used in treatment for acromegaly, pituitary adenoma, carcinoid, gastrinoma, glucagonoma, variceal bleeding?

Octreotide

4

Drug used to activate FSH receptors for controlled ovarian hyperstimulation and for management of infertility due to hypogonadism in men

Follitropin Alfa

5

LH analog

Choriogonadotropin alfa
HCG
Menotropins
Lutropin

6

GnRH analog which increases LH and FSH with intermittent administration and reduces LH and FSH with prolonged continuous administration.
Used for the treatment of endometriosis, myoma uteri, precocious puberty and prostate cancer

Leuprolide

7

GnRH antagonist used in prostate cancer and prevention of premature LH surge

Ganirelix
Cetrorelix
Abarelix
Degarelix
Note: does not cause a tumor flare up when used for treatment of advanced prostate cancer

8

Dopamine agonist but a partial agonist at dopamine D2 receptors in the brain to inhibit prolactin release

Bromocriptine
Pergolide
Carbergoline
Quinagolide

9

What is the side effect of bromocriptine other than erythromelalgia and pulmonary fibrosis?

raynaud phenomenon

10

What is the drug of choice for treatment of pregnant hyperthyroid patients which has a slow onset of action (3-4 weeks to take full effect)

Propylthiouracil
Drug class: Thioamide

11

What is the mechanism of action of propylthiouracil?

It inhibits thyroid peroxidase reactions
It inhibits iodine organification and peripheral conversion of T4 and T3

12

What is the treatment of choice for Myxedema coma (progressive weakness, stupor, hypothermia, hypoventilation, hypoglycemia, hyponatremia, water intoxication, shock and death due to severe hypoglycemia)

IV loading dose of Levothyroxine 300-400 mcg

13

What are the side effects of Propylthiouracil?

Agranulocytosis, Urticaria, Fulminant Hepatitis, Lupus-like syndrome, vasculitis, Hypoprothrombinemia, Exfoliative dermatitis, Polyserositis, Arthralgia

14

Prenatal exposure to Methimazole results to?

Aplasia cutis congenita

15

What is the treatment that reduces the size and vascularity of thyroid gland. MOA includes inhibiting iodine organification and hormone release?

Lugol's solution
Potassium Iodide

16

What do you call the phenomenon in which the ingestion of iodine causes hypothyroidism?

Wolf-Chaikoff effect

17

What do you call the phenomenon in which the ingestion of iodine causes hyperthyroidism?

Jod-Basedow effect

18

What is the drug that cause clinical improvement without altering thyroid hormone levels. It inhibits peripheral conversion of T4 and T3

Propranolol

19

What are the three drugs that inhibits peripheral conversion of T4 to T3

Propylthiouracil
Propranolol
Hydrocortisone

20

What is the drug of choice for thyroid storm?

Propylthiouracil then Iodides to retard release of thyroid hormones

21

Give three drugs that induces hyperthyroidism?

Clofibrate
Amiodarone
Methadone

22

What drug induces hypo and hyperthyroidism?

Amiodarone
- Has the ability to block the peripheral conversion of T4 to T3 (Tx: Levothyroxine)
- Iodine induced mechanism in persons with an underlying disease or through an inflammatory mechanism that causes leakage of thyroid hormone
(tx: Thioamides or corticosteroids)

23

What glucocorticoid synthesis inhibitor that inhibits desmolase and reduced synthesis of all hormonally active steroids used in the treatment of breast cancer and cushing syndrome?

Aminogluthemide
Note: Used by body builders to lower circulating levels of cortisol in the body and prevent muscle loss

24

Which among the azole antifungals inhibits cholesterol side-chain cleavage, cytochrome P450 and other enzymes necessary for synthesis of all steroids? Used in the treatment of adrenal carcinoma, hirsutism, breast cancer, prostate cancer, cushing's syndrome and fungal infections

Ketoconazole

25

What glucocorticoid synthesis inhibitor that selectively inhibits steroid 11-hydroxylation used in the diagnostic testing for Cushing's syndrome? This is also the drug of choice for pregnant patients with cushing's syndrome

Metyrapone

26

Examples of progestins

Norgestrel
Norethindrone
Ethynodiol
Megestrol
Desogestrel
Norelgestromin
Norgestimate
Etonorgestrel

27

What are the side effects of progestins?

Decreased HDL and Weight gain

28

What progestin is used as an appetite stimulant

Megestrol

29

What is the drug used as an emergency contraception

Levonorgestrel
(YUZPE regimen)

30

What is the drug used as a progestin-only pill?

Medroxyprogesterone acetate
IM: Devo-Provera