Autocoids

Question 1

Examples of 1st Generation H1 receptor antagonist

Answer 1

Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine

Question 2

Examples of 2nd generation H1 receptor antagonist

Answer 2

Cetirizine
Loratadine
Fexofenadine
Desloratadine
Terfenadine
Astemizole

Note: no autonomic or anti-motion sickness effect unlike the 1st generation anti-histamine

Question 3

What is the drug interaction between azoles/erythromycin and terfenadine/astemizole

Answer 3

fatal arrythmia

Question 4

Examples of H2 receptor antagonist which is used in the reduction of gastric acid secretion?

Answer 4

Cimetidine
Ranitidine
Famotidine
Nizatidine

Question 5

What H2 receptor antagonist that can cause gynecomastia?

Answer 5

Cimetidine

Question 6

What is the drug of choice for acute migraine?

Answer 6

Sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan

Question 7

What is the mechanism of action of sumatriptan?

Answer 7

Inhibits 5-HT1D/1B in the braindrugs

Question 8

What is a 5HT2 receptor antagonist that is used in the treatment of migraine and cluster headache?

Answer 8

Ergotamine, Dihydroergotamine, Methysergide

Question 9

What is a 5HT2 receptor antagonist that can cause retroperitoneal fibrosis?

Answer 9

Methysergide

Question 10

What is a 5HT2 receptor antagonist that is used in postpartum bleeding?

Answer 10

Ergonovine, Methylergonovine

Question 11

What is a prostaglandin E1 analog that is used in the treatment of peptic ulcer disease and NSAID induced gastric mucosal injury?

Answer 11

Misoprostol

Gemeprost

Question 12

What is the teratogenic effect of Misoprostol?

Answer 12

Mobius sequence

Question 13

What is a prostaglandin E1 analog used in the maintenance of patent ductus arteriosus and used in treating erectile dysfunction?

Answer 13

Alprastodil

MOA: activates EP receptors causing vascular smooth muscle relaxation and vasodilation

Question 14

What is the side effect of the prostaglandin E1 analog used in the maintenance of patent ductus arteriosus?

Answer 14

Priapism

Question 15

What is a Prostaglandin F2alpha analog used in controlling postpartum hemorrhage

Answer 15

CARBAPROST
Bimatoprost
Travoprost
Unoprostone

Question 16

What is a prostaglandin E2 receptor analog used in cervical ripening for induction of labor

Answer 16

DINOPROSTONE

Sulprostone

Question 17

What is a prostaglanding I1 analog used in the treatment of pulmonary hypertension and reduces platelet aggregation in dialysis machines

Answer 17

ENOPROSTENOL
Beraprost
Iloprost
Treprostinil

Question 18

What is a prostaglandin F2alpha analog used in the treatment of glaucoma (increases outflow of aqueous humor and reduces intraocular pressure)?

Answer 18

LATANOPROST
Bimatoprost
Travoprost
Unoprostone

Question 19

What are examples of short-acting beta2-selective receptor agonist used in the treatment of asthma?

Answer 19

ALBUTEROL/SALBUTAMOL
Levalbuterol
TERBUTALINE
Metaproterenol
Pirbuterol
Procaterol
Fenoterol

Question 20

What are examples of long-acting beta2-selective receptor agonist?

Answer 20

Salmeterol
Formoterol
Celeneterol
Bambuterol

Question 21

What is a muscarinic receptor antagonist use d in the treatment of asthma by prevetning vagal-stimulated vagoconstriction?

Answer 21

Ipratropium, Tiotropium

Question 22

What drugs are phosphodiesterase inhibitors and adenosine receptor antagonists used in the treatment of asthma?

Answer 22

Theophylline (Narrow therapeutic window)
Aminophylline
Pentoxifylline

Question 23

Examples of mast cell stabilizers used in the treatment of asthma

Answer 23

Cromolyn
Nedocromil
Lodoxamide

Question 24

What is the drug of choice for asthma anaphylaxis?

Answer 24

Fluticasone

Similar drugs: Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone

Question 25

What is the mechanism of action of steroids in treating asthma?

Answer 25

Phospholipase A2 inhibitor

Question 26

What is the side effect of fluticasone?

Answer 26

Oropharyngeal candidiasis

Question 27

what is the treatment for severe refractory asthma (status asthmaticus)

Answer 27

IV hydrocortisone

Question 28

What is the steroid that has the lowest systemic steroid toxicity?

Answer 28

Ciclesonide

Question 29

What is a leukotriene synthesis inhibitor which acts by inhibiting 5-lipooxygenase and which is used as asthma prophylaxis and in the treatment of exercise, antigen, and aspirin-induced bronchospasm?

Answer 29

Zileuton

Question 30

Examples of leukotriene antagonist which acts by blocking cysteinyl leukotriene-1 receptor for Leukotrienes C4, D4 and E4

Answer 30

Monteleukast, Zafirlukast, Pranlukast

Question 31

What is a rare side effect of leukotriene antagonists?

Answer 31

Churg-Strauss Syndrome | allergic angiits and granulomatous invovlement in the lung, associated with eosinophilia

Question 32

What is a drug that acts as an anti-IgE antibody?

Answer 32

Omalizumab