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Flashcards in Autocoids Deck (32)
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1

Examples of 1st Generation H1 receptor antagonist

Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine

2

Examples of 2nd generation H1 receptor antagonist

Cetirizine
Loratadine
Fexofenadine
Desloratadine
Terfenadine
Astemizole

Note: no autonomic or anti-motion sickness effect unlike the 1st generation anti-histamine

3

What is the drug interaction between azoles/erythromycin and terfenadine/astemizole

fatal arrythmia

4

Examples of H2 receptor antagonist which is used in the reduction of gastric acid secretion?

Cimetidine
Ranitidine
Famotidine
Nizatidine

5

What H2 receptor antagonist that can cause gynecomastia?

Cimetidine

6

What is the drug of choice for acute migraine?

Sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan

7

What is the mechanism of action of sumatriptan?

Inhibits 5-HT1D/1B in the braindrugs

8

What is a 5HT2 receptor antagonist that is used in the treatment of migraine and cluster headache?

Ergotamine, Dihydroergotamine, Methysergide

9

What is a 5HT2 receptor antagonist that can cause retroperitoneal fibrosis?

Methysergide

10

What is a 5HT2 receptor antagonist that is used in postpartum bleeding?

Ergonovine, Methylergonovine

11

What is a prostaglandin E1 analog that is used in the treatment of peptic ulcer disease and NSAID induced gastric mucosal injury?

Misoprostol
Gemeprost

12

What is the teratogenic effect of Misoprostol?

Mobius sequence

13

What is a prostaglandin E1 analog used in the maintenance of patent ductus arteriosus and used in treating erectile dysfunction?

Alprastodil
MOA: activates EP receptors causing vascular smooth muscle relaxation and vasodilation

14

What is the side effect of the prostaglandin E1 analog used in the maintenance of patent ductus arteriosus?

Priapism

15

What is a Prostaglandin F2alpha analog used in controlling postpartum hemorrhage

CARBAPROST
Bimatoprost
Travoprost
Unoprostone

16

What is a prostaglandin E2 receptor analog used in cervical ripening for induction of labor

DINOPROSTONE
Sulprostone

17

What is a prostaglanding I1 analog used in the treatment of pulmonary hypertension and reduces platelet aggregation in dialysis machines

ENOPROSTENOL
Beraprost
Iloprost
Treprostinil

18

What is a prostaglandin F2alpha analog used in the treatment of glaucoma (increases outflow of aqueous humor and reduces intraocular pressure)?

LATANOPROST
Bimatoprost
Travoprost
Unoprostone

19

What are examples of short-acting beta2-selective receptor agonist used in the treatment of asthma?

ALBUTEROL/SALBUTAMOL
Levalbuterol
TERBUTALINE
Metaproterenol
Pirbuterol
Procaterol
Fenoterol

20

What are examples of long-acting beta2-selective receptor agonist?

Salmeterol
Formoterol
Celeneterol
Bambuterol

21

What is a muscarinic receptor antagonist use d in the treatment of asthma by prevetning vagal-stimulated vagoconstriction?

Ipratropium, Tiotropium

22

What drugs are phosphodiesterase inhibitors and adenosine receptor antagonists used in the treatment of asthma?

Theophylline (Narrow therapeutic window)
Aminophylline
Pentoxifylline

23

Examples of mast cell stabilizers used in the treatment of asthma

Cromolyn
Nedocromil
Lodoxamide

24

What is the drug of choice for asthma anaphylaxis?

Fluticasone
(Similar drugs: Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone)

25

What is the mechanism of action of steroids in treating asthma?

Phospholipase A2 inhibitor

26

What is the side effect of fluticasone?

Oropharyngeal candidiasis

27

what is the treatment for severe refractory asthma (status asthmaticus)

IV hydrocortisone

28

What is the steroid that has the lowest systemic steroid toxicity?

Ciclesonide

29

What is a leukotriene synthesis inhibitor which acts by inhibiting 5-lipooxygenase and which is used as asthma prophylaxis and in the treatment of exercise, antigen, and aspirin-induced bronchospasm?

Zileuton

30

Examples of leukotriene antagonist which acts by blocking cysteinyl leukotriene-1 receptor for Leukotrienes C4, D4 and E4

Monteleukast, Zafirlukast, Pranlukast