Flashcards in Autocoids Deck (32)
Examples of 1st Generation H1 receptor antagonist
Examples of 2nd generation H1 receptor antagonist
Note: no autonomic or anti-motion sickness effect unlike the 1st generation anti-histamine
What is the drug interaction between azoles/erythromycin and terfenadine/astemizole
Examples of H2 receptor antagonist which is used in the reduction of gastric acid secretion?
What H2 receptor antagonist that can cause gynecomastia?
What is the drug of choice for acute migraine?
Sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan
What is the mechanism of action of sumatriptan?
Inhibits 5-HT1D/1B in the braindrugs
What is a 5HT2 receptor antagonist that is used in the treatment of migraine and cluster headache?
Ergotamine, Dihydroergotamine, Methysergide
What is a 5HT2 receptor antagonist that can cause retroperitoneal fibrosis?
What is a 5HT2 receptor antagonist that is used in postpartum bleeding?
What is a prostaglandin E1 analog that is used in the treatment of peptic ulcer disease and NSAID induced gastric mucosal injury?
What is the teratogenic effect of Misoprostol?
What is a prostaglandin E1 analog used in the maintenance of patent ductus arteriosus and used in treating erectile dysfunction?
MOA: activates EP receptors causing vascular smooth muscle relaxation and vasodilation
What is the side effect of the prostaglandin E1 analog used in the maintenance of patent ductus arteriosus?
What is a Prostaglandin F2alpha analog used in controlling postpartum hemorrhage
What is a prostaglandin E2 receptor analog used in cervical ripening for induction of labor
What is a prostaglanding I1 analog used in the treatment of pulmonary hypertension and reduces platelet aggregation in dialysis machines
What is a prostaglandin F2alpha analog used in the treatment of glaucoma (increases outflow of aqueous humor and reduces intraocular pressure)?
What are examples of short-acting beta2-selective receptor agonist used in the treatment of asthma?
What are examples of long-acting beta2-selective receptor agonist?
What is a muscarinic receptor antagonist use d in the treatment of asthma by prevetning vagal-stimulated vagoconstriction?
What drugs are phosphodiesterase inhibitors and adenosine receptor antagonists used in the treatment of asthma?
Theophylline (Narrow therapeutic window)
Examples of mast cell stabilizers used in the treatment of asthma
What is the drug of choice for asthma anaphylaxis?
(Similar drugs: Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone)
What is the mechanism of action of steroids in treating asthma?
Phospholipase A2 inhibitor
What is the side effect of fluticasone?
what is the treatment for severe refractory asthma (status asthmaticus)
What is the steroid that has the lowest systemic steroid toxicity?
What is a leukotriene synthesis inhibitor which acts by inhibiting 5-lipooxygenase and which is used as asthma prophylaxis and in the treatment of exercise, antigen, and aspirin-induced bronchospasm?
Examples of leukotriene antagonist which acts by blocking cysteinyl leukotriene-1 receptor for Leukotrienes C4, D4 and E4
Monteleukast, Zafirlukast, Pranlukast
What is a rare side effect of leukotriene antagonists?
(allergic angiits and granulomatous invovlement in the lung, associated with eosinophilia)