Flashcards in Autocoids Deck (32)
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1
Examples of 1st Generation H1 receptor antagonist
Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine
2
Examples of 2nd generation H1 receptor antagonist
Cetirizine
Loratadine
Fexofenadine
Desloratadine
Terfenadine
Astemizole
Note: no autonomic or anti-motion sickness effect unlike the 1st generation anti-histamine
3
What is the drug interaction between azoles/erythromycin and terfenadine/astemizole
fatal arrythmia
4
Examples of H2 receptor antagonist which is used in the reduction of gastric acid secretion?
Cimetidine
Ranitidine
Famotidine
Nizatidine
5
What H2 receptor antagonist that can cause gynecomastia?
Cimetidine
6
What is the drug of choice for acute migraine?
Sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan
7
What is the mechanism of action of sumatriptan?
Inhibits 5-HT1D/1B in the braindrugs
8
What is a 5HT2 receptor antagonist that is used in the treatment of migraine and cluster headache?
Ergotamine, Dihydroergotamine, Methysergide
9
What is a 5HT2 receptor antagonist that can cause retroperitoneal fibrosis?
Methysergide
10
What is a 5HT2 receptor antagonist that is used in postpartum bleeding?
Ergonovine, Methylergonovine
11
What is a prostaglandin E1 analog that is used in the treatment of peptic ulcer disease and NSAID induced gastric mucosal injury?
Misoprostol
Gemeprost
12
What is the teratogenic effect of Misoprostol?
Mobius sequence
13
What is a prostaglandin E1 analog used in the maintenance of patent ductus arteriosus and used in treating erectile dysfunction?
Alprastodil
MOA: activates EP receptors causing vascular smooth muscle relaxation and vasodilation
14
What is the side effect of the prostaglandin E1 analog used in the maintenance of patent ductus arteriosus?
Priapism
15
What is a Prostaglandin F2alpha analog used in controlling postpartum hemorrhage
CARBAPROST
Bimatoprost
Travoprost
Unoprostone
16
What is a prostaglandin E2 receptor analog used in cervical ripening for induction of labor
DINOPROSTONE
Sulprostone
17
What is a prostaglanding I1 analog used in the treatment of pulmonary hypertension and reduces platelet aggregation in dialysis machines
ENOPROSTENOL
Beraprost
Iloprost
Treprostinil
18
What is a prostaglandin F2alpha analog used in the treatment of glaucoma (increases outflow of aqueous humor and reduces intraocular pressure)?
LATANOPROST
Bimatoprost
Travoprost
Unoprostone
19
What are examples of short-acting beta2-selective receptor agonist used in the treatment of asthma?
ALBUTEROL/SALBUTAMOL
Levalbuterol
TERBUTALINE
Metaproterenol
Pirbuterol
Procaterol
Fenoterol
20
What are examples of long-acting beta2-selective receptor agonist?
Salmeterol
Formoterol
Celeneterol
Bambuterol
21
What is a muscarinic receptor antagonist use d in the treatment of asthma by prevetning vagal-stimulated vagoconstriction?
Ipratropium, Tiotropium
22
What drugs are phosphodiesterase inhibitors and adenosine receptor antagonists used in the treatment of asthma?
Theophylline (Narrow therapeutic window)
Aminophylline
Pentoxifylline
23
Examples of mast cell stabilizers used in the treatment of asthma
Cromolyn
Nedocromil
Lodoxamide
24
What is the drug of choice for asthma anaphylaxis?
Fluticasone
(Similar drugs: Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone)
25
What is the mechanism of action of steroids in treating asthma?
Phospholipase A2 inhibitor
26
What is the side effect of fluticasone?
Oropharyngeal candidiasis
27
what is the treatment for severe refractory asthma (status asthmaticus)
IV hydrocortisone
28
What is the steroid that has the lowest systemic steroid toxicity?
Ciclesonide
29
What is a leukotriene synthesis inhibitor which acts by inhibiting 5-lipooxygenase and which is used as asthma prophylaxis and in the treatment of exercise, antigen, and aspirin-induced bronchospasm?
Zileuton
30
Examples of leukotriene antagonist which acts by blocking cysteinyl leukotriene-1 receptor for Leukotrienes C4, D4 and E4
Monteleukast, Zafirlukast, Pranlukast
31
What is a rare side effect of leukotriene antagonists?
Churg-Strauss Syndrome
(allergic angiits and granulomatous invovlement in the lung, associated with eosinophilia)
32
