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Flashcards in Cancer Drugs Deck (38)
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1

Rescue for methotrexate

Leucovirin

2

Inhibits thymidilate synthase

5 FU

3

"Rescue" for 5 FU

Uridine

4

Causes panyctopenia and cerebellar dysfunction

Cytarabine
Arabynofuranosyl cytidine

5

Decreases de novo purine synthesis

Azathioprine
6MP
6TG

6

Drug for SLE

Azathioprine

7

Increased toxicity with allopurinol

Azathioprine
6MP

8

Uses for Dactinomycin

Wilma tumor
Ewing sarcoma
Rhabdomyosarcoma

9

Causes cardio toxicity

Doxorubicin
Trastuzumab

10

Causes pulmonary fibrosis

Bleomycin
Busulfan

11

Drugs for testicular CA

Bleomycin
Ego posive
Vinblastine

12

Causes hemorrhagic cystitis

Cyclophosphamide

13

Antidote for cyclophosphamide

Mesna

14

Crosses the BBB

Nitrosoureas-carmustine, lomustine, semustine, steptozocin

15

Acts on the M phase

Vinca alkaloids
Taxols

16

Causes neurotoxicity

Vincristine

17

Acts on the M phase and causes bone marrow suppression

Vinblastine

18

For ovarian and breast CA

Paclitaxel and other taxols

19

Hyperstabilize polymerized microtubule a in M phase

Paclitacel and another taxols

20

Causes Nephrotoxicity and acoustic nerve damage

Cisplatin, carboplatin

21

Prevent Nephrotoxicity through scavenging free radicals

Amifostine

22

Inhibits topoisomerase II - DNA degradation

Etoposide, teniposide

23

Inhibits topoisomerase I - prevent DNA unwinding and replication

Irinotecan, topotecan

24

For colon CA

Irinotecan

25

For small cell lung CA

Topotecan

26

Inhibits ribonucleotide reductase - decreases DNA synthesis

Hydroxyurea

27

Selective estrogen receptor modulator

Tamoxifen, raloxifen

28

For breast CA, causes endometrial CA

Tamoxifen

29

Prevents osteoporosis
Endometrial antagonist

Raloxifen

30

Monoclonal antibody against HER 2

Trastuzumab (Herceptin)