Flashcards in Antivirals Deck (19)
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1
Inhibits guanine nucleotide synthesis by inhibiting inosine monophosphate dehydrogenase
Ribavirin
2
Tx for RSV, HepC
Toxicity
Ribavirin
Anemia, Teratogen
3
Guanosine analog
Inhibits viral DNA polymerase
HSV/VZV thymidine kinase
Acyclovir, Famcyclovir, Valacyclovir
4
Tx for HSV, VZV
Toxicity
Acyclovir
Valacyclovir - better oral bioavailability
Famciclovir - herpes zoster
Crystalline neuropathy, acute renal failure
5
Guanosine analog
Inhibits viral DNA polymerase
CMV viral kinase
Ganciclovir
6
Tx for CMV
Toxicity
Ganciclovir
Valgancyclovir - better oral bioavailability
Leukopenia, neutropenia, thrombocytopenia, renal toxicity
7
Viral DNA pol inhibitor
Binds to pyrophosphate binding site
Foscarnet
8
Tx CMV retinitis
Toxicity
Foscarnet
Nephrotoxicity
9
Protease inhibitors toxicity
Hyperglycemia, lipodystrophy, hematuria
10
NRTIs toxicity
Bone marrow suppression
Peripheral neuropathy - nucleosides
Lactic acidosis - non nucleosides
Anemia - zdv
Pancraetitis - didanosine
11
NNRTIs toxicity
Rash and hepatotoxicity
Vivid dreams, CNS symptoms - Efavirenz
Contraindicated in pregnancy - Delavirdine, Efavirenz
12
Raltegravir toxicity
Hypercholesterolemia
13
Enfuvirtide MOA
Binds gp41, inhibiting entry
14
Maravaroc MOA
Binds CCR , inhibiting interacts with gp120
15
Raltegavir MOA
Reversible inhibits HIV integrase
16
IFN beta
Multiple sclerosis
17
IFN gamma
Chronic granulomatous disease
18
IFN alpha
Hep B and C
Kaposi sarcoma
Hairy cell leukemia
Condylomata acuminatum
Renal cell CA
Malignant melanoma
19
