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Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

(19 cards)

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1
Q

Inhibits guanine nucleotide synthesis by inhibiting inosine monophosphate dehydrogenase

A

Ribavirin

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2
Q

Tx for RSV, HepC

Toxicity

A

Ribavirin

Anemia, Teratogen

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3
Q

Guanosine analog
Inhibits viral DNA polymerase
HSV/VZV thymidine kinase

A

Acyclovir, Famcyclovir, Valacyclovir

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4
Q

Tx for HSV, VZV

Toxicity

A

Acyclovir
Valacyclovir - better oral bioavailability
Famciclovir - herpes zoster
Crystalline neuropathy, acute renal failure

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5
Q

Guanosine analog
Inhibits viral DNA polymerase
CMV viral kinase

A

Ganciclovir

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6
Q

Tx for CMV

Toxicity

A

Ganciclovir
Valgancyclovir - better oral bioavailability
Leukopenia, neutropenia, thrombocytopenia, renal toxicity

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7
Q

Viral DNA pol inhibitor

Binds to pyrophosphate binding site

A

Foscarnet

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8
Q

Tx CMV retinitis

Toxicity

A

Foscarnet

Nephrotoxicity

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9
Q

Protease inhibitors toxicity

A

Hyperglycemia, lipodystrophy, hematuria

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10
Q

NRTIs toxicity

A 
Bone marrow suppression
Peripheral neuropathy - nucleosides
Lactic acidosis - non nucleosides
Anemia - zdv
Pancraetitis - didanosine
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11
Q

NNRTIs toxicity

A

Rash and hepatotoxicity
Vivid dreams, CNS symptoms - Efavirenz
Contraindicated in pregnancy - Delavirdine, Efavirenz

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12
Q

Raltegravir toxicity

A

Hypercholesterolemia

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13
Q

Enfuvirtide MOA

A

Binds gp41, inhibiting entry

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14
Q

Maravaroc MOA

A

Binds CCR , inhibiting interacts with gp120

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15
Q

Raltegavir MOA

A

Reversible inhibits HIV integrase

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16
Q

IFN beta

Study These Flashcards
A

Multiple sclerosis

17
Q

IFN gamma

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A

Chronic granulomatous disease

18
Q

IFN alpha

Study These Flashcards
A 
Hep B and C
Kaposi sarcoma
Hairy cell leukemia
Condylomata acuminatum
Renal cell CA
Malignant melanoma
19
Q

Inhibits influenza neuraminidase

Study These Flashcards
A

Zanamivir

Oseltamivir

Pharmacology (13 decks)

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