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Flashcards in Antivirals Deck (19)
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1

Inhibits guanine nucleotide synthesis by inhibiting inosine monophosphate dehydrogenase

Ribavirin

2

Tx for RSV, HepC
Toxicity

Ribavirin
Anemia, Teratogen

3

Guanosine analog
Inhibits viral DNA polymerase
HSV/VZV thymidine kinase

Acyclovir, Famcyclovir, Valacyclovir

4

Tx for HSV, VZV
Toxicity

Acyclovir
Valacyclovir - better oral bioavailability
Famciclovir - herpes zoster
Crystalline neuropathy, acute renal failure

5

Guanosine analog
Inhibits viral DNA polymerase
CMV viral kinase

Ganciclovir

6

Tx for CMV
Toxicity

Ganciclovir
Valgancyclovir - better oral bioavailability
Leukopenia, neutropenia, thrombocytopenia, renal toxicity

7

Viral DNA pol inhibitor
Binds to pyrophosphate binding site

Foscarnet

8

Tx CMV retinitis
Toxicity

Foscarnet
Nephrotoxicity

9

Protease inhibitors toxicity

Hyperglycemia, lipodystrophy, hematuria

10

NRTIs toxicity

Bone marrow suppression
Peripheral neuropathy - nucleosides
Lactic acidosis - non nucleosides
Anemia - zdv
Pancraetitis - didanosine

11

NNRTIs toxicity

Rash and hepatotoxicity
Vivid dreams, CNS symptoms - Efavirenz
Contraindicated in pregnancy - Delavirdine, Efavirenz

12

Raltegravir toxicity

Hypercholesterolemia

13

Enfuvirtide MOA

Binds gp41, inhibiting entry

14

Maravaroc MOA

Binds CCR , inhibiting interacts with gp120

15

Raltegavir MOA

Reversible inhibits HIV integrase

16

IFN beta

Multiple sclerosis

17

IFN gamma

Chronic granulomatous disease

18

IFN alpha

Hep B and C
Kaposi sarcoma
Hairy cell leukemia
Condylomata acuminatum
Renal cell CA
Malignant melanoma

19

Inhibits influenza neuraminidase

Zanamivir
Oseltamivir