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Flashcards in Opioids Deck (19)
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1

What is the opioid that has the shortest half-life?

Remifentanil

2

What is the opioid with the longest half life

Buprenorphine

3

What are the opioid receptors and their effects?

Mu = ihibition of respiration
Delta = tolerance
Kappa = Slowed gastrointestinal transit

4

What is the mechanism of action of morphine?

Morphine is an opioid analgesic (full agonist)
strong agonist at mu receptors

5

What is the most potent opioid?

Ohmefentanyl

6

What is the mechanism of action of meperidine?

Strong agonist at mu and kappa receptors

7

What is the side effect of meperidine when given with SSRIs or MAOIs

Serotonin syndrome

8

What is the treatment for opioid dependence that acts as a strong agonist at mu receptors and binds NMDA receptors and antagonizes the effects of glutamate? It is currently being investigated as a novel treatment for leukemia

Methadone

9

What is the side effect of Methadone?

Drug induced hyperthyroidism

10

What opiod analgesic that acts as a mu and kappa receptor agonist that has a side effect of hypogonadism and hearing loss?

Hydrocodone
Oxycodone

11

What partial opioid analgesic that decreases sensitivity of cough receptors and depresses the medullary cough center through sigma receptor?

Dextrometorphan
Codeine

12

What opioid analgesic that acts as a weak agonist at mu receptor that is used in the treatment of restless legs syndrome and opioid withdrawal?

Propoxyphene
Levopropoxyphene
Dextropropoxyphene
Note: withdrawn from the market due to fatal cardiotoxicity

13

What is a mixed opioid agonist-antagonist (strong agonist at K receptors, weak antagonist activity at mu receptors?

Nalbuphine
Similar drugs: Buprenorphine, Butorphanol, Pentazocine

14

What is the drug that is used to reduce craving in alcohol dependence

Buprenorphine

15

What is the drug used in opioid toxicity? this drug precipitates abstinence syndrome in patients with opiod dependence

Naloxone
Naltrexone
Nalmefene

16

What is the opioid antagonist that reduces craving in alcohol dependence

Naltrexone

17

What opioid analgesic which is dual-acting (weak agonist at mu receptor and inhibits neuronal reuptake of serotonin and norepinephrine)?

Tramadol
Tapentadol

18

What is the side effect of Tramadol?

Lowers seizure threshold
Contraindicated in patients with a history of epilepsy

19

What is the triad of opioid overdose?

Pupillary constriction
Comatose state
Respiratory depression