Flashcards in Opioids Deck (19)
What is the opioid that has the shortest half-life?
What is the opioid with the longest half life
What are the opioid receptors and their effects?
Mu = ihibition of respiration
Delta = tolerance
Kappa = Slowed gastrointestinal transit
What is the mechanism of action of morphine?
Morphine is an opioid analgesic (full agonist)
strong agonist at mu receptors
What is the most potent opioid?
What is the mechanism of action of meperidine?
Strong agonist at mu and kappa receptors
What is the side effect of meperidine when given with SSRIs or MAOIs
What is the treatment for opioid dependence that acts as a strong agonist at mu receptors and binds NMDA receptors and antagonizes the effects of glutamate? It is currently being investigated as a novel treatment for leukemia
What is the side effect of Methadone?
Drug induced hyperthyroidism
What opiod analgesic that acts as a mu and kappa receptor agonist that has a side effect of hypogonadism and hearing loss?
What partial opioid analgesic that decreases sensitivity of cough receptors and depresses the medullary cough center through sigma receptor?
What opioid analgesic that acts as a weak agonist at mu receptor that is used in the treatment of restless legs syndrome and opioid withdrawal?
Note: withdrawn from the market due to fatal cardiotoxicity
What is a mixed opioid agonist-antagonist (strong agonist at K receptors, weak antagonist activity at mu receptors?
Similar drugs: Buprenorphine, Butorphanol, Pentazocine
What is the drug that is used to reduce craving in alcohol dependence
What is the drug used in opioid toxicity? this drug precipitates abstinence syndrome in patients with opiod dependence
What is the opioid antagonist that reduces craving in alcohol dependence
What opioid analgesic which is dual-acting (weak agonist at mu receptor and inhibits neuronal reuptake of serotonin and norepinephrine)?
What is the side effect of Tramadol?
Lowers seizure threshold
Contraindicated in patients with a history of epilepsy