Antimycobacterial Drugs Flashcards Preview

Block 5 > Antimycobacterial Drugs > Flashcards

Flashcards in Antimycobacterial Drugs Deck (91)
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1

treatment of active TB

4 drugs-
isoniazid
rifampin
pyrazinamide
ethambutol

2

treatment of MDR-TB

5-6 drugs

3

latent TB treatment

isoniazid or rifampin alone for 9 months

4

locations of TB drugs

intracellular
extracellular
cavities

5

speed of intracellular replication

slow

6

speed of extracellular replication

fast

7

speed of cavitary replication

slow

8

mycolic acid

long chain branched fatty acids in the wall

9

mycelia acid benefits

resist dehdyration, disinfectants, antibiotics, hide from macrophages

10

isoniazid works at

extra
intra
cavity

11

isoniazid is cidal or static

either- depends on location

12

isoniazid MOA

prodrug activated to nicotinoyl radical by Katg which inhibits mycolic acid synthesis by blocking InhA and KasA

13

KatG

mycobacterium enzyme that activates isoniazid to nicotinoyl radical

14

nicotinoyl radical

active form of isoniazid

15

InhA

acyl carrier protein reductase

16

KasA

acyl carrier protein synthetase

17

isoniazid resistance mechanisms

spontaneous resistance
KatG mutation
InhA overexpression
resistance to oxidative stress

18

isoniazid clearance

NAT2 aceylation in liver which is then either excreted by kidney oR converted to hydrazine by cops
acetylated and excreted

19

what increases isoniazid toxicity

slow acetylators
cyp inducers

20

isoniazid side effects

hepatotoxicity
neurotoxicity- PNS and CNS

21

prevention of isoniazid side effects

B6 supplements

22

isoniazid interactions

inhibits MAO- do not give with tyramine foods, excessive caffeine, MAOI

cyp inhibitors
alcohol

23

extracellular acting first line tb drugs

isoniazid
rifampin
ethambutol
streptomycin

24

intracellular acting first line tb drugs

isoniazid
rifampin
pyrazinamide

25

cavity acting first line tb drugs

isoniazid
rifampin
ethambutol

26

rifampin acts in

intracellular
extracellular
cavity

27

rifampin cidal or static

cidal

28

rifampin MOA

inhibits bacterial RNA polymerase

29

rifampin resistance

RNA polymerase mutations

30

rifampin clearance

deacetylation in liver