Mucoactive drugs Flashcards Preview

Block 5 > Mucoactive drugs > Flashcards

Flashcards in Mucoactive drugs Deck (27):
1

hypertonic saline

expectorant- hydrates PCL and decreases mucus viscosity
cough
used in CF

2

guaifenesin

expectorant
increases secretions and reduce viscosity
cholinergic induced cough (vagal and gastric nerves)
combined with DM

3

acetylcysteine

mucolytic- splits disulfide bonds between mucin monomers
anti inflammatory/anti oxidant properties to neutralize free thiol reactivity

4

dornase alpha

mucolytic
DNAse cleaves DNA tangles in mucus to reduce viscosity in CF

5

albuterol

beta agonist
bronchodilator

6

formoterol

beta agonist
bronchodilator

7

metaproternol

beta agonist
bronchodilator

8

pirbuterol

beta agonist
bronchodilator

9

salmeterol

beta agonist
bronchodilator

10

calfactant "factant"

pulmonary surfactant
holds alveoli open

11

anticholinergics

mucoregulators
ipratropium bromide
tiotropium bromide
block vagal tone for airway dilation and decreased mucus production

12

inhaled corticosteroids

mucoregulators
"sone"

13

oral corticosteroids

prednisone

14

omalizumab

anti-inflammatory biologic- anti IgE

15

mucoactive drug

changes the production, secretion, composition, and/or interactions of mucous with mucociliary epithelium

16

expectorants

induces cough
increase volume of secretion

17

mucolytics

reduce mucus viscosity

18

mucokinetics

increase mucus mobility

19

mucoregulators

control mucus secretion

20

mucus

network of glycosylated mucin filaments
thiol cross links
bound by non-covalent bonds

21

guaifenesin ADR

rare GI disturbances, dizzinness, headache, rash
nephrolithiasis (excessive use)- metabolite of drug is in stones

22

guaifenesin use

sinusitis
pharyngitis
bronchitis
asthma

23

acetylcysteine use

atelectasis
COPD
CF
bronchitis

24

acetylcysteine ADR

smells bad- hide in something if PO
bronchospasms if inhaled- give with beta agonist

25

Dornase alpha ADR

hypersensitivity- made in CHO cells

26

surfactant ADR

dosing- hypoxia from injecting a liquid, bradycardia
after- hyperopia, hypocapnia from rapid increase in oxygenation
hypersenitivity

27

macrolides

clear pseudomonas
anti inflammatory
decrease mucus secretion