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Block 5 > Lung 6 > Flashcards

Lung 6 Flashcards

(54 cards)

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1
Q

age range for lung cancer

A

40-70y

peak 50-60y

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2
Q

most common genetic mutation in lung cancer in non smokers

A

EGFR

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3
Q

rare genetic mutation in lung cancer of non smokers

A

KRAS

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4
Q

occasional genetic mutation in lung cancer of non smokers

A

TP53

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5
Q

cancer associated with ex smokers and non smokers

A

adenocarcinoma

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6
Q

cancer associated with current smokers

A

squamous cell

small cell

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7
Q

adenocarcinoma precursors

A

atypical adenomatous hyperplasia
adenocarcinom in situ
microinvasive

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8
Q

atypical adenomatous hyperplasia

A

adenocarcinoma precursor

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9
Q

adenocarcinoma in situ

A

adenocarcinoma precursor

>5mm

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10
Q

microinvasive adenocarcinoma

A

adenocarcinoma precursor

tumor

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11
Q

mucinous adenocarcinoma

A

spreads through air spaces and forms satellite tumors
grows along septa
worse prognosis

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12
Q

non mucinous adenocarcinoma

A

peripheral nodule
better prognosis
“butterflies on a fence”

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13
Q

adenocarcioma location

A

peripheral

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14
Q

adenocarcinomas marker

A

thyroid transcription factor 1

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15
Q

squamous cell carcinoma location

A

central

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16
Q

speed of adenocarcinoma growth

A

slow

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17
Q

speed of squamous cell carcinoma growth

A

fast

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18
Q

squamous cell carcinoma precursor

A

bronchial epithelium metaplasia/dysplasia

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19
Q

mutation associated with adenocarcinoma

A

KRAS

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20
Q

mutation associated with squamous cell carcinoma

A

FGFR, CDKN2A, TP53

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21
Q

adenocarcinoma growth pattern

A

along septa

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22
Q

squamous cell growth pattern

Study These Flashcards
A

into air spaces creating obstruction

23
Q

squamous cell carcinoma looks like

Study These Flashcards
A

TB- areas of hemorrhage and necrosis with cavitation

cauliflower like intraparenchymal mass

24
Q

PET positive tumor

Study These Flashcards
A

squamous cell

25
histological findings for squamous cell
pink | keratin pearls
26
precursor lesion for small cell
diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
27
location of small cell
central OR peripheral
28
most aggressive lung cancer
small cell
29
most likely to metastasize
small cell
30
cancers that are not curable surgically
squamous cell | small cell
31
most associated with paraneoplastic syndromes
small cell
32
histology for small cell
small blue cells poorly defined boarders little cytoplasm high mitotic count
33
Azzopardi effect
vascular walls stain blue from the DNA released from necrotic cells
34
small cell markers
chromogranin synaptophysin CD56
35
worst type of cancer
small cell
36
small cell mutations
TP53 RB MYC amplifications
37
squamous cell marker
PET positive
38
large cell carcinoma diagnosis
diagnosis of exclusion | all markers negative
39
location of large cell carcinoma
peripheral
40
secondary pathology 6
``` partial obstruction total obstruction impaired drainage pulmonary abscess SVC syndrome pericarditis/pleuritis ```
41
hypercalcemia is most associated with
squamous cell
42
paraneoplastic syndromes 6
``` ADH ACTH PTH calcitonin gonadotropins serotonin/bradykinin ```
43
Lambert-Eaton myasthenic syndrome
muscle weakness from autoantibodies against calcium channels
44
Trousseau syndrome
systemic presentation of lung cancer DVT and thromboembolism hypercoagulable state
45
hypertrophic pulmonary osteoarthropathy
systemic presentation of lung cancer abnormal connective tissues clubbing
46
Pancoast tumors and symptoms
apical tumors that compress neural structures around trachea | Horner's syndrome + ulnar distribution pain
47
lung cancer metastis route
lymph | blood
48
lung cancer metastasis location
adrenal liver brain bone
49
molecular pathway targets
``` EGFR ALK MET VEGF PD-L1 ```
50
pulmonary hamartoma
benign, well circumscribed coin lesion
51
difference between secondary and primary lung cancer
secondary- multiple discrete mets | primary- single lesion
52
marker for asbestos exposure
fibrous pleural plaques
53
mesothelioma
asbestos related pleura neoplasm long latency- 25-45y less likely than lung cancer after exposure
54
most common site of lung cancer metastasis
adrenal glands

Block 5 (27 decks)

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